Hyptadienic acid
Based on 1 Customer Validation
Hyptadienic acid is a triterpene acid that can be isolated from the leaves of Perilla frutescens. Hyptadienic acid inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice with an ID50 value of 0.13 mg/ear. Hyptadienic acid can be used for the research of inflammation.
For research use only. We do not sell to patients.
- Purity : 93.0%
- CAS No.: 128397-09-1
- Formula: C30H46O4
- Molecular Weight:470.68
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
24.68 μM
Compound: 32
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Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
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[PMID: 20515057] |
| A549 | IC50 |
7.4 μM
Compound: 37
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Anticancer activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Anticancer activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 37146221] |
| HL-60 | IC50 |
15.48 μM
Compound: 32
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Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
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[PMID: 20515057] |
| MCF7 | IC50 |
>10 μM
Compound: 37
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Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 37146221] |
| MCF7 | IC50 |
>40 μM
Compound: 32
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Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
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[PMID: 20515057] |
| MDA-MB-231 | IC50 |
>10 μM
Compound: 37
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Anticancer activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Anticancer activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 37146221] |
| NCI-H1975 | IC50 |
>10 μM
Compound: 37
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Anticancer activity against human NCI-H1975 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Anticancer activity against human NCI-H1975 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 37146221] |
| SMMC-7721 | IC50 |
21.01 μM
Compound: 32
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Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay
Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay
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[PMID: 20515057] |
| SW480 | IC50 |
10.86 μM
Compound: 32
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Cytotoxicity against human SW480 cells after 48 hrs by MTT assay
Cytotoxicity against human SW480 cells after 48 hrs by MTT assay
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[PMID: 20515057] |
Chemical Information
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CAS No. 128397-09-1
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Appearance Solid
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Molecular Weight 470.68
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Formula C30H46O4
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Color White to off-white
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SMILES
C[C@@]12C([C@@]3([H])[C@](C(O)=O)(CC[C@@H](C)[C@]3(O)C)CC2)=CC[C@@]4([H])[C@]1(CC[C@]5([H])[C@@]4(C(CO)=CC5(C)C)C)C
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Protocols
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hyptadienic acid Related Classifications
HY-N4024 Related Classifications
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