Cytidine-5'-triphosphate
Based on 3 publication(s) in Google Scholar
Cytidine-5'-triphosphate (Cytidine triphosphate) is a nucleoside triphosphate and a substrate of CMP-KDO synthase, forming CMP-KDO. Cytidine-5'-triphosphate is a precursor of RNA/DNA, phospholipids, and sialoglycoproteins, is reduced to dCTP by deoxycytidylate-generating reductase, and can be used for the biosynthesis of phosphatidic acid to CDP-DG/cardiolipin.
For research use only. We do not sell to patients.
- Purity : 98.16%
- CAS No.: 65-47-4
- Formula: C9H16N3O14P3
- Molecular Weight:483.16
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-W013093
Uridine triphosphate trisodium saltUTP -
HY-B2176
ATPEndogenous Metabolite -
HY-12695
Guanosine triphosphate trisodiumCellular Metabolism Regulator -
HY-W010737
Guanosine triphosphate disodiumCellular Metabolism Regulator -
HY-101981
Uridine 5'-monophosphateNucleotide Analogue -
HY-101981R
Uridine 5'-monophosphate (Standard)Nucleotide Analogue -
HY-W009162
Cytidine 5'-monophosphateEndogenous Metabolite -
HY-W010918
Adenosine 5'-diphosphate -
HY-Y0649
Lithium chloride, 99.3%-TBiochemical Reagent -
HY-113225H
GTP trisodium salt, 100 mM Solution, PCR GradeSolution Prepared by GTP -
HY-A0181
Adenosine monophosphateAdenosine A1 Receptor Agonist -
HY-B0445
NAD+Endogenous Metabolite
Publications Citing Use of MedChemExpress (MCE) Cytidine-5'-triphosphate
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
Description
In Vitro
Cytidine-5'-triphosphate is reduced to deoxycytidylic acid at a rate of 1230 mμmol dCMP/hr/mg protein in a cell-free assay using purified enzyme from Lactobacillus leichmannii ATCC 7830 in the absence of Fraction K, indicating that the reduction occurs at the triphosphate level[5].
Cytidine-5'-triphosphate is consumed and converted to dCTP under conditions using purified L. leichmannii ATCC 7830 enzyme with Fraction K omitted[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 65-47-4
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Appearance Solid
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Molecular Weight 483.16
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Formula C9H16N3O14P3
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Color White to off-white
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SMILES
O[C@H]1[C@@H](O)[C@H](N2C(N=C(N)C=C2)=O)O[C@@H]1COP(OP(OP(O)(O)=O)(O)=O)(O)=O
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Synonyms
Cytidine triphosphate; 5'-CTP
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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Exp Hematol Oncol
CTP synthase 2 predicts inferior survival and mediates DNA damage response via interacting with BRCA1 in chronic lymphocytic leukemia. [Abstract]2023 Jan 12;12(1):6. PMID: 36635772 -
Redox Biol
CTPS1 modulates mitophagy to propel diffuse large B-cell lymphoma via reshaping CEPT1-mediated phospholipid metabolism. [Abstract]2026 May:92:104132. PMID: 41865720 -
Anal Chim Acta
2021 Dec 15:1188:339180. PMID: 34794559
Solvent & Solubility
In Vitro:
H2O : ≥ 200 mg/mL (413.94 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (206.97 mM); Clear solution; Need ultrasonic
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (288 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Boghaei DM, et al. Spectrophotometric studies of molecular complex formation between water-soluble cobalt(II) Schiff base complex and nucleotides in mixed solvent systems. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2005 Oct;61(13-14):3061-5. [Content Brief]
[8]. Hatch GM, et al. Regulation of cardiolipin biosynthesis in H9c2 cardiac myoblasts by cytidine 5'-triphosphate. J Biol Chem. 1996 Oct 18;271(42):25810-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.0697 mL | 10.3485 mL | 20.6971 mL | 51.7427 mL |
| 5 mM | 0.4139 mL | 2.0697 mL | 4.1394 mL | 10.3485 mL | |
| 10 mM | 0.2070 mL | 1.0349 mL | 2.0697 mL | 5.1743 mL | |
| 15 mM | 0.1380 mL | 0.6899 mL | 1.3798 mL | 3.4495 mL | |
| 20 mM | 0.1035 mL | 0.5174 mL | 1.0349 mL | 2.5871 mL | |
| 25 mM | 0.0828 mL | 0.4139 mL | 0.8279 mL | 2.0697 mL | |
| 30 mM | 0.0690 mL | 0.3450 mL | 0.6899 mL | 1.7248 mL | |
| 40 mM | 0.0517 mL | 0.2587 mL | 0.5174 mL | 1.2936 mL | |
| 50 mM | 0.0414 mL | 0.2070 mL | 0.4139 mL | 1.0349 mL | |
| 60 mM | 0.0345 mL | 0.1725 mL | 0.3450 mL | 0.8624 mL | |
| 80 mM | 0.0259 mL | 0.1294 mL | 0.2587 mL | 0.6468 mL | |
| 100 mM | 0.0207 mL | 0.1035 mL | 0.2070 mL | 0.5174 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Cytidine-5'-triphosphate Related Classifications
HY-125818 Related Classifications
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