Cytidine-5'-triphosphate
Based on 3 publication(s) in Google Scholar
Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii.
For research use only. We do not sell to patients.
- Purity: 98.16%
- CAS No.: 65-47-4
- Formula: C9H16N3O14P3
- Molecular Weight:483.16
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Publications Citing Use of MedChemExpress (MCE) Cytidine-5'-triphosphate
MoreAll DNA/RNA Synthesis Isoforms
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
Cytidine-5'-triphosphate is an important nucleotide that participates in a variety of biosynthetic processes, especially the phospholipid synthesis and DNA/RNA replication and transcription. Cytidine-5'-triphosphate is the precursor for the synthesis of phosphatidylglycerol (PG), phosphatidylinositol (PI) and cardiolipin (CL). Cytidine-5'-triphosphate is the inhibitor for spartate transcarbamylase, thereby regulating the synthesis rate of pyrimidine nucleotides[2][3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 65-47-4
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Appearance Solid
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Molecular Weight 483.16
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Formula C9H16N3O14P3
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Color White to off-white
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SMILES
O[C@H]1[C@@H](O)[C@H](N2C(N=C(N)C=C2)=O)O[C@@H]1COP(OP(OP(O)(O)=O)(O)=O)(O)=O
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Synonyms
Cytidine triphosphate; 5'-CTP
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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Exp Hematol Oncol
CTP synthase 2 predicts inferior survival and mediates DNA damage response via interacting with BRCA1 in chronic lymphocytic leukemia. [Abstract]2023 Jan 12;12(1):6. PMID: 36635772 -
Redox Biol
CTPS1 modulates mitophagy to propel diffuse large B-cell lymphoma via reshaping CEPT1-mediated phospholipid metabolism. [Abstract]2026 May:92:104132. PMID: 41865720 -
Anal Chim Acta
2021 Dec 15:1188:339180. PMID: 34794559
Solvent & Solubility
H2O : ≥ 200 mg/mL (413.94 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (206.97 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Heidy Y Narvaez-Ortiz, et al. A CTP Synthase Undergoing Stage-Specific Spatial Expression Is Essential for the Survival of the Intracellular Parasite Toxoplasma gondii. Front Cell Infect Microbiol. 2018 Mar 22;8:83. [Content Brief]
[2]. Hatch GM, et al., Regulation of cardiolipin biosynthesis in H9c2 cardiac myoblasts by cytidine 5'-triphosphate. J Biol Chem. 1996 Oct 18;271(42):25810-6. [Content Brief]
[3]. Matsumoto S, et al., An equilibrium binding study of the interaction of aspartate transcarbamylase with cytidine 5'-triphosphate and adenosine 5'-triphosphate. Biochemistry. 1973 Mar 27;12(7):1388-94. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.0697 mL | 10.3485 mL | 20.6971 mL | 51.7427 mL |
| 5 mM | 0.4139 mL | 2.0697 mL | 4.1394 mL | 10.3485 mL | |
| 10 mM | 0.2070 mL | 1.0349 mL | 2.0697 mL | 5.1743 mL | |
| 15 mM | 0.1380 mL | 0.6899 mL | 1.3798 mL | 3.4495 mL | |
| 20 mM | 0.1035 mL | 0.5174 mL | 1.0349 mL | 2.5871 mL | |
| 25 mM | 0.0828 mL | 0.4139 mL | 0.8279 mL | 2.0697 mL | |
| 30 mM | 0.0690 mL | 0.3450 mL | 0.6899 mL | 1.7248 mL | |
| 40 mM | 0.0517 mL | 0.2587 mL | 0.5174 mL | 1.2936 mL | |
| 50 mM | 0.0414 mL | 0.2070 mL | 0.4139 mL | 1.0349 mL | |
| 60 mM | 0.0345 mL | 0.1725 mL | 0.3450 mL | 0.8624 mL | |
| 80 mM | 0.0259 mL | 0.1294 mL | 0.2587 mL | 0.6468 mL | |
| 100 mM | 0.0207 mL | 0.1035 mL | 0.2070 mL | 0.5174 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Cytidine-5'-triphosphate Related Classifications
HY-125818 Related Classifications
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