65-47-4
65-47-4
Chemical Structure
Cytidine-5'-triphosphate
Synonym(s): Cytidine triphosphate; 5'-CTP
- CAS No.: 65-47-4
- Formula:C9H16N3O14P3
- Molecular Weight:483.16
IUPAC Name: ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate
InChIKey: PCDQPRRSZKQHHS-XVFCMESISA-N
SMILES: O[C@H]1[C@@H](O)[C@H](N2C(N=C(N)C=C2)=O)O[C@@H]1COP(OP(OP(O)(O)=O)(O)=O)(O)=O
Biological Activity: Cytidine-5'-triphosphate (Cytidine triphosphate) is a nucleoside triphosphate and a substrate of CMP-KDO synthase, forming CMP-KDO. Cytidine-5'-triphosphate is a precursor of RNA/DNA, phospholipids, and sialoglycoproteins, is reduced to dCTP by deoxycytidylate-generating reductase, and can be used for the biosynthesis of phosphatidic acid to CDP-DG/cardiolipin[1][2][3][4][5][6][7][8].
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Cytidine-5'-triphosphate | 98.16% | Cytidine-5'-triphosphate (Cytidine triphosphate) is a nucleoside triphosphate and a substrate of CMP-KDO synthase, forming CMP-KDO. Cytidine-5'-triphosphate is a precursor of RNA/DNA, phospholipids, and sialoglycoproteins, is reduced to dCTP by deoxycytidylate-generating reductase, and can be used for the biosynthesis of phosphatidic acid to CDP-DG/cardiolipin. | ||||||||||||||||||||
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Cytidine-5'-triphosphate-13C9 dilithium | 99.00% | Cytidine-5'-triphosphate-13C9 (Cytidine triphosphate-13C9 dilithium; 5'-CTP-13C9) dilithium is 13C-labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii. The product specifications provided below refer solely to the active content of Cytidine-5'-triphosphate-13C9 dilithium. |
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Cytidine-5'-triphosphate-13C,d1 dilithium | 97.1% | Cytidine-5'-triphosphate-13C,d1 (Cytidine triphosphate-13C,d1 dilithium; 5'-CTP-13C,d1) dilithium is deuterium and 13C-labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii. The product specifications provided below refer solely to the active content of Cytidine-5'-triphosphate-13C,d1 dilithium. |
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Cytidine-5'-triphosphate-15N3,d14 dilithium | Cytidine-5'-triphosphate-15N3,d14 (Cytidine triphosphate-15N3,d14 dilithium; 5'-CTP-15N3,d14) dilithium is deuterium and 15N labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii. | |||||||||||||||||||||
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Cytidine-5'-triphosphate-15N3 dilithium | 97.0% | Cytidine-5'-triphosphate-15N3 (Cytidine triphosphate-15N3 dilithium; 5'-CTP-15N3) dilithium is 15N labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii. The product specifications provided below refer solely to the active content of Cytidine-5'-triphosphate-15N3 dilithium. |
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Cytidine-5′-triphosphate-d14 disodium | 98.00% | Cytidine-5′-triphosphate-d14 disodium is the deuterium labeled Cytidine-5'-triphosphate. Cytidine 5′-triphosphate (Cytidine triphosphate;5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii. The product specifications provided below refer solely to the active content of Cytidine-5′-triphosphate-d14 disodium. |
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Cytidine-5'-triphosphate-13C5 | Cytidine-5'-triphosphate-13C5 (Cytidine triphosphate-13C5) is the 13C-labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule?in the de novo?pyrimidine biosynthetic pathway in?T. gondii. | |||||||||||||||||||||
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Cytidine-5'-triphosphate-d14 dilithium | 98.2% | Cytidine-5'-triphosphate-d14 (Cytidine triphosphate-d14 dilithium; 5'-CTP-d14) dilithium is deuterium labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii. The product specifications provided below refer solely to the active content of Cytidine-5'-triphosphate-d14 dilithium. |
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Structural Analogs
-
Similarity Score 1.00
HY-115740Cytarabine triphosphate -
Similarity Score 0.89
HY-113400Cytidine 5'-diphosphate -
Similarity Score 0.88
HY-178659N4-Methyl-CTP -
Similarity Score 0.87
HY-178575CTPαS (Rp isomer) -
Similarity Score 0.87
HY-178577CTPαS -
Similarity Score 0.87
HY-178658CTPαS (Sp isomer) -
Similarity Score 0.87
HY-W7845692'-OMe-CTP -
Similarity Score 0.86
HY-125818ICTP disodium salt, 100 mM Solution, PCR Grade -
Similarity Score 0.84
HY-1771653'-NH2-CTP -
Explore the MedChemAI to find more analogs
References
- [1]. Boghaei DM, et al. Spectrophotometric studies of molecular complex formation between water-soluble cobalt(II) Schiff base complex and nucleotides in mixed solvent systems. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2005 Oct;61(13-14):3061-5. [Content Brief]
- [2]. Simon ES, et al. Convenient Syntheses of Cytidine 5'-Triphosphate, Guanosine 5'-Triphosphate, and Uridine 5'-Triphosphate and Their Use in the Preparation of UDP-glucose, UDP-glucuronic Acid, and GDP-mannose. J Org Chem. 1990;55(6):1834-1841.
- [3]. Kizaki H, et al. Increased cytidine 5'-triphosphate synthetase activity in rat and human tumors. Cancer Res. 1980 Nov;40(11):3921-7.
- [4]. Ray PH, et al. Purification and characterization of cytidine 5'-triphosphate:cytidine 5'-monophosphate-3-deoxy-D-manno-octulosonate cytidylyltransferase. Journal of bacteriology. 1981 Mar;145(3):1273-80.
- [5]. Abrams R. Cytidine 5'-Triphosphate as the Precursor of Deoxycytidylate in Lactobacillus leichmannii. J Biol Chem. 1965;240(9):PC3697.
- [6]. Von der Saal W, et al. Cytidine-5'-triphosphate synthetase catalyzes the phosphorylation of uridine 5'-triphosphate by adenosine 5'-triphosphate. J Am Chem Soc. 1985;107(3):703-704.
- [7]. van Haperen VW, Vet al. Regulation of phosphorylation of deoxycytidine and 2',2'-difluorodeoxycytidine (gemcitabine); effects of cytidine 5'-triphosphate and uridine 5'-triphosphate in relation to chemosensitivity for 2',2'-difluorodeoxycytidine. Biochem Pharmacol. 1996 Apr 12;51(7):911-8.
- [8]. Hatch GM, et al. Regulation of cardiolipin biosynthesis in H9c2 cardiac myoblasts by cytidine 5'-triphosphate. J Biol Chem. 1996 Oct 18;271(42):25810-6. [Content Brief]
