2. GPCR/G Protein
  3. Endothelin Receptor
  4. Endothelin-2 (49-69), human TFA

Endothelin-2 (49-69), human TFA  (Synonyms: Endothelin-2 (49-69) (human, canine) TFA; Human endothelin-2 TFA)

Cat. No.: HY-P0207A Purity: 99.21%
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Endothelin-2 (49-69), human (TFA) (Endothelin-2 (49-69) (human, canine) (TFA)) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

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Endothelin-2 (49-69), human TFA

Endothelin-2 (49-69), human TFA Chemical Structure

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Other Forms of Endothelin-2 (49-69), human TFA:

Endothelin-2 (49-69), human TFA Related Antibodies

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Description

Endothelin-2 (49-69), human (TFA) (Endothelin-2 (49-69) (human, canine) (TFA)) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

In Vitro

At nanomolar concentrations, Endothelin-2 exhibits a strong and long-lasting vasoconstrictor activity characteristic of endothelin (EC50=0.52 nM)[1].
Endothelin-2 is a chemoattractant for macrophages and THP-1 monocytic cells, but not for freshly isolated monocytes. The chemotactic response to Endothelin-2 shows a typical bell-shaped response curve. Experiments with endothelin receptor antagonists shows that migration to Endothelin-2 is mediated via the ET-RB receptor. Endothelin-2 expression by tumors may modulate the behavior of macrophages such that activated cells accumulate in areas of hypoxia[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Endothelin-2 (49-69), human TFA Related Antibodies
In Vivo

Two distinct phases of pressor effects are typically seen in response to Endothelin-2: the early phase immediately follows the depressor response and dominates during the next 3-10 min, whereas the late pressor effect develops 10-20 min after the injection and lasts >1 hr[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

2546.92 (free base)

Formula

C115H160N26O32S4·xC2HF3O2
Appearance

Solid

Color

White to off-white

Sequence

Cys-Ser-Cys-Ser-Ser-Trp-Leu-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridge: Cys1-Cys15, Cys3-Cys11)
Sequence Shortening

CSCSSWLDKECVYFCHLDIIW (Disulfide bridge: Cys1-Cys15, Cys3-Cys11)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL

H2O : 6.67 mg/mL (ultrasonic and adjust pH to 3 with HCl)

*"≥" means soluble, but saturation unknown.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
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Endothelin-2 (49-69), human TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Endothelin-2 (49-69), humanEndothelin-2 (49-69) (human, canine)Human endothelin-2Human endothelin2Human endothelin 2Endothelin Receptor21-aminoacidvasoactivepeptideG-protein-linkedtransmembraneET-RAET-RBInhibitorinhibitorinhibit

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