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  2. Endothelin-2 (49-69), human TFA

Endothelin-2 (49-69), human TFA (Synonyms: Endothelin-2 (49-69) (human, canine) TFA; Human endothelin-2 TFA)

Cat. No.: HY-P0207A
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Endothelin-2 (49-69), human (TFA) (Endothelin-2 (49-69) (human, canine) (TFA)) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

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Endothelin-2 (49-69), human TFA Chemical Structure

Endothelin-2 (49-69), human TFA Chemical Structure

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Endothelin-2 (49-69), human (TFA) (Endothelin-2 (49-69) (human, canine) (TFA)) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

In Vitro

At nanomolar concentrations, Endothelin-2 exhibits a strong and long-lasting vasoconstrictor activity characteristic of endothelin (EC50=0.52 nM)[1].
Endothelin-2 is a chemoattractant for macrophages and THP-1 monocytic cells, but not for freshly isolated monocytes. The chemotactic response to Endothelin-2 shows a typical bell-shaped response curve. Experiments with endothelin receptor antagonists shows that migration to Endothelin-2 is mediated via the ET-RB receptor. Endothelin-2 expression by tumors may modulate the behavior of macrophages such that activated cells accumulate in areas of hypoxia[2].

In Vivo

Two distinct phases of pressor effects are typically seen in response to Endothelin-2: the early phase immediately follows the depressor response and dominates during the next 3-10 min, whereas the late pressor effect develops 10-20 min after the injection and lasts >1 hr[1].

Molecular Weight





Cys-Ser-Cys-Ser-Ser-Trp-Leu-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridge: Cys1-Cys15, Cys3-Cys11)

Sequence Shortening

CSCSSWLDKECVYFCHLDIIW (Disulfide bridge: Cys1-Cys15, Cys3-Cys11)


Room temperature in continental US; may vary elsewhere.


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Endothelin-2 (49-69), humanEndothelin-2 (49-69) (human, canine)Human endothelin-2Human endothelin2Human endothelin 2Others21-aminoacidvasoactivepeptideG-protein-linkedtransmembraneET-RAET-RBInhibitorinhibitorinhibit

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