dGTP-13C10,15N5 dilithium
Based on 1 Customer Validation
dGTP-13C10,15N5 (2'-Deoxyguanosine-5'-triphosphate-13C10,15N5) dilithium is 13C and 15N-labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.2%
- 화학식: 13C10H14Li215N5O13P3
- 분자량:533.94
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보관:
Solution, -20°C, 2 years
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 2564-35-4
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Appearance Liquid
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분자량 533.94
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화학식 13C10H14Li215N5O13P3
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Color Colorless to light yellow
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SMILES
O=P(O)(O[Li])OP(OP(O[13CH2][13C@H]1O[13C@@H]([15N]2[13C]([15N]=[13C]([15NH2])[15NH][13C]3=O)=[13C]3[15N]=[13CH]2)[13CH2][13C@@H]1O)(O)=O)(O[Li])=O
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Synonyms
2'-Deoxyguanosine-5'-triphosphate-13C10,15N5 dilithium
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Solution, -20°C, 2 years
순도&문서
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Kapoor I, et al. Nucleoside Diphosphate Kinase Escalates A-to-C Mutations in MutT-Deficient Strains of Escherichia coli. J Bacteriol. 2019;202(1):e00567-19. Published 2019 Dec 6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
dGTP-13C10,15N5 dilithium Related Classifications
HY-138616S4 Related Classifications
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