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Magnesium Lithospermate B 

Cat. No.: HY-126415
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Magnesium Lithospermate B is a derivative of caffeic acid tetramer and extracted from Salviae miltiorrhizae. Magnesium Lithospermate B is widely used for the research of cardiovascular diseases, and it can protect against glucose-induced intracellular oxidative damage. Magnesium Lithospermate B also suppresses neuroinflammation and attenuates neurodegeneration.

For research use only. We do not sell to patients.

Magnesium Lithospermate B Chemical Structure

Magnesium Lithospermate B Chemical Structure

CAS No. : 122021-74-3

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Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Magnesium Lithospermate B is a derivative of caffeic acid tetramer and extracted from Salviae miltiorrhizae. Magnesium Lithospermate B is widely used for the research of cardiovascular diseases, and it can protect against glucose-induced intracellular oxidative damage. Magnesium Lithospermate B also suppresses neuroinflammation and attenuates neurodegeneration[1][2][3].

In Vitro

Magnesium Lithospermate B (20-60 μg/ml; 24 h) decreases LDH activity in the cultured supernatant, increases SOD activity in cardiomyocytes, reduces intracellular ROS and MDA levels, and significantly suppresses cardiomyocytes apoptosis[2].
Magnesium Lithospermate B (1-100 μg/ml) enhances proliferation of neural stem cells (NSCs) in a dose-dependent manner[3].
Magnesium Lithospermate B (10 μg/ml) promotes the differentiation in vitro of NSCs towards neurons[3].

In Vivo

Magnesium Lithospermate B (2-8 mg/kg; p.o. once daily for 16 d) reduces the renal damage of oxidative stress through reduction of reactive oxygen species in old rats[1].
Magnesium Lithospermate B (0.5 μg/g; s.c. for 6 weeks) promotes the neurogenesis and improves the memory in PD models[3].

Animal Model: Young (5-month-old) and old (20-month-old) specific-pathogen-free male Sprague-Dawley rats[1]
Dosage: 2, 8 mg/kg
Administration: P.o. once daily for 16 days
Result: Reduced the protein expression of major subunits of nicotinamide adenine dinucleotide phosphate oxidase (Nox4 and p22phox), phospho-p38, nuclear factor-kappa B p65, cyclooxygenase-2, and inducible nitric oxide synthase.
Showed lower levels of senescence-related proteins such as p16, ADP-ribosylation factor 6, p53, and p21.
Molecular Weight

740.90

Formula

C₃₆H₂₈MgO₁₆

CAS No.

122021-74-3

SMILES

O=C1[O-][Mg+2]23O=C(/C=C\C4=C5[[email protected]](C(O[[email protected]](CC6=CC=C(C(O)=C6)O)C([O-]3)=O)=O2)[[email protected]@H](C7=CC=C(C(O)=C7)O)OC5=C(O)C=C4)O[[email protected]@H]1CC8=CC=C(C(O)=C8)O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Magnesium Lithospermate BOtherscaffeicacidtetramerSalviaemiltiorrhizaecardiovasculardiseasesoxidativedamageneuroin?ammationInhibitorinhibitorinhibit

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Magnesium Lithospermate B
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