Pestanoid A
Pestanoid A is a rearranged pimarane diterpenoid osteoclastogenesis inhibitor with an IC50 of 4.2 μM. Pestanoid A can be isolated from the marine mesophotic zone chalinidae sponge-associated fungus, Pestalotiopsis sp. NBUF145. Pestanoid A inhibits the receptor activator of NF-kB ligand-induced MAPK and NF-κB signaling by suppressing the phosphorylation of ERK1/2-JNK1/2-p38 MAPKs and NF-κB nuclear translocation. Pestanoid A can be used for the study of osteoporosis.
For research use only. We do not sell to patients.
- Formula: C20H26O6
- Molecular Weight:362.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Monocyte | CC50 |
>30 μM
Compound: 1
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Cytotoxicity against C57BL/6 mouse bone marrow monocytes assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against C57BL/6 mouse bone marrow monocytes assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38194474] |
| Monocyte | IC50 |
4.2 μM
Compound: 1
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Anti-osteoclastogensis in C57BL/6 mouse bone marrow monocytes assessed as inhibition of RANKL/M-CSF induced osteoclastogenesis at 10 uM incubated for 5 days
Anti-osteoclastogensis in C57BL/6 mouse bone marrow monocytes assessed as inhibition of RANKL/M-CSF induced osteoclastogenesis at 10 uM incubated for 5 days
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[PMID: 38194474] |
Chemical Information
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Molecular Weight 362.42
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Formula C20H26O6
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SMILES
C=C1CC[C@@]2([H])[C@@](C(C(C[C@@]3(C)[C@H](CO)OC(C3)=O)=CC(O2)=O)=O)(C)[C@@H]1C
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Structure Classification
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Initial Source
Pestalotiopsis
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pestanoid A Related Classifications
HY-N12561 Related Classifications
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