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Polygalacturonic acid  (Synonyms: Galacturonic acid polymer)

Cat. No.: HY-N6613 Purity: ≥95.0%
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Polygalacturonic acid (Galacturonic acid polymer) is transparent colloid, is a major component of the cell wall. Polygalacturonic acid can be used to prepare silver nanoparticles (AgNPs), as an antioxidant and anti-inflammatory that protect cells from destructive effect of elevated ROS and accelerate wound healing. Polygalacturonic acid nanoparticles also displays anti-bacterial activity.

For research use only. We do not sell to patients.

Polygalacturonic acid Chemical Structure

Polygalacturonic acid Chemical Structure

CAS No. : 25990-10-7

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Polygalacturonic acid Related Antibodies

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Description

Polygalacturonic acid (Galacturonic acid polymer) is transparent colloid, is a major component of the cell wall. Polygalacturonic acid can be used to prepare silver nanoparticles (AgNPs), as an antioxidant and anti-inflammatory that protect cells from destructive effect of elevated ROS and accelerate wound healing. Polygalacturonic acid nanoparticles also displays anti-bacterial activity[1][2].

In Vitro

Polygalacturonic acid can be used to format a durable hydrogel, to prolong the effect of drugs. Polygalacturonic acid hydrogel/hyaluronate, conjugated Ibuprofen (HY-78131) for example, prevents epidural fibrosis, the severe scar tissue adhesion of laminectomized male adult rats, and increases the efficiency of local inflammation control and reduces the side-effect of Ibuprofen[1].
Polygalacturonic acid hydrogel/hyaluronate (PGA-HA) (2%, 200 μL; 24 h) shows low cytotoxicity on L929 fibroblasts[1].
Polygalacturonic acid (PGA) preparing (Ag-PGA/HA)-PVA nanoparticles, shows anti-bacterial activity against gram-positive bacterial strains; Bacillus Subtilis and Staphylococcus Aureus, as well as gram-negative bacterial strain; Escherichia Coli[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Polygalacturonic acid Related Antibodies
In Vivo

Polygalacturonic acid (external application; 14 d) enhances a quick healing of wound infection in albino rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Full thickness wound model in albino rats (60-day-old, 180 g)[2]
Dosage: Ag-Polygalacturonic acid/hyaluronic acid nanoparticles
Administration: Applied on dorsal muscle fascia; cleaned the wound daily with alcohol; for 14 days
Result: Resulted no sign of abscess formation or hypertrophic scars both in the early phase; 5th day or in the final phase; 14th day, respectively.
Showed significant wound healing from day 8 while treated with (Ag-PGA/HA)-PVA nanofiber and blank (PGA/HA)-PVA nanofiber and induced epithelization on day 14.
Formula

(C6H10O7)x
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(O)=O.[x]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 5 mg/mL (ultrasonic and warming and heat to 60°C)

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Purity & Documentation

Purity: ≥95.0%

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Polygalacturonic acid25990-10-7Galacturonic acid polymerOthersantibacterialhyaluronic acidnanofiberpolygalacturonic acidsilver nanoparticleswound dressingepidural fibrosisibuprofeninjectable hydrogelprostaglandin E2Inhibitorinhibitorinhibit

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