H-Gly-Sar-OH
Based on 1 publication(s) in Google Scholar
H-Gly-Sar-OH (Glycylsarcosine; Gly-Sar) is a dipeptide formed by the condensation of glycine and sarcosine. H-Gly-Sar-OH can be used to study the function and transport mechanism of PEPT1.
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- Purity : 99.87%
- CAS No.: 29816-01-1
- 화학식: C5H10N2O3
- 분자량:146.14
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보관:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) H-Gly-Sar-OH
More
Biological Activity
제품 설명
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDCK | EC50 |
0.54 mM
Compound: 37
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Activation of human PEPT1 expressed in MDCK cells
Activation of human PEPT1 expressed in MDCK cells
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[PMID: 16759105] |
| MDCK | IC50 |
1.16 mM
Compound: 37
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Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells
Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells
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[PMID: 16759105] |
In Vitro
H-Gly-Sar-OH uptake in rabbit intestinal brush-border membrane vesicles is maximal in Mannitol (D-Mannitol) (HY-N0378) medium and is not stimulated by an inward Na+ or other monovalent cation gradient; Na+ reduces uptake to 74% of control[3].
H-Gly-Sar-OH uptake in rabbit intestinal brush-border membrane vesicles is stimulated by an inside-negative K+ diffusion potential, indicating the presence of electrogenic transport associated with net positive charge movement[3].
H-Gly-Sar-OH depolarizes rabbit intestinal brush-border membrane vesicles both in the presence and absence of Na+, consistent with electrogenic Gly-Sar transport[3].
H-Gly-Sar-OH inhibits the uptake of Gly-Pro (Glycyl-L-proline) (HY-W016887) in rabbit intestinal brush-border membrane vesicles with a KI of 20.8 mM, whereas Gly-Pro inhibits the uptake of Gly-Sar with a KI of 2.8 mM, supporting the existence of a shared peptide transport system with different apparent affinities[3].
H-Gly-Sar-OH binds purified E. coli DppA with an estimated binding constant of approximately 0.6 mM[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 29816-01-1
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Appearance Solid
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분자량 146.14
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화학식 C5H10N2O3
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Color White to off-white
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Synonyms
Glycylsarcosine; Gly-Sar
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Sequence
Gly-{Sar}
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Sequence Shortening
G-{Sar}
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Food Chem X
Preparation, characterization, assembly, and stability of walnut peptide - zinc complexes and its ability to promote zinc transport in Caco-2 cells. [Abstract]2025 Sep 16:31:103046. PMID: 41036460
용액&용해도
In Vitro:
H2O : 41.67 mg/mL (285.14 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
순도&문서
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Data Sheet (274 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 6.8428 mL | 34.2138 mL | 68.4275 mL | 171.0688 mL |
| 5 mM | 1.3686 mL | 6.8428 mL | 13.6855 mL | 34.2138 mL | |
| 10 mM | 0.6843 mL | 3.4214 mL | 6.8428 mL | 17.1069 mL | |
| 15 mM | 0.4562 mL | 2.2809 mL | 4.5618 mL | 11.4046 mL | |
| 20 mM | 0.3421 mL | 1.7107 mL | 3.4214 mL | 8.5534 mL | |
| 25 mM | 0.2737 mL | 1.3686 mL | 2.7371 mL | 6.8428 mL | |
| 30 mM | 0.2281 mL | 1.1405 mL | 2.2809 mL | 5.7023 mL | |
| 40 mM | 0.1711 mL | 0.8553 mL | 1.7107 mL | 4.2767 mL | |
| 50 mM | 0.1369 mL | 0.6843 mL | 1.3686 mL | 3.4214 mL | |
| 60 mM | 0.1140 mL | 0.5702 mL | 1.1405 mL | 2.8511 mL | |
| 80 mM | 0.0855 mL | 0.4277 mL | 0.8553 mL | 2.1384 mL | |
| 100 mM | 0.0684 mL | 0.3421 mL | 0.6843 mL | 1.7107 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
H-Gly-Sar-OH Related Classifications
HY-W010276 Related Classifications
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