Glycyl-L-proline
Based on 1 publication(s) in Google Scholar
Glycyl-L-proline (H-Gly-Pro-OH) is a dipeptide. Glycyl-L-proline can induce MCF-7 cells apoptosis. Glycyl-L-proline can enhance the inhibitory effect of the PRODH/POX knockout on collagen and DNA biosynthesis. Glycyl-L-proline can inhibit Gly-Sar and L-proline transport. Glycyl-L-proline can be used for the researches of cancer and metabolic disease, such as breast cancer.
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- Pureza: 99.88%
- No. CAS: 704-15-4
- Fòrmula: C7H12N2O3
- Peso molecular:172.18
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Almacenamiento:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Glycyl-L-proline
MoreVer todos los productos específicos de isoformas Endogenous Metabolite
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Actividad biológica
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Human Endogenous Metabolite |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDCK | EC50 |
0.13 mM
Compound: 36
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Activation of human PEPT1 expressed in MDCK cells
Activation of human PEPT1 expressed in MDCK cells
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[PMID: 16759105] |
| MDCK | IC50 |
0.33 mM
Compound: 36
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Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells
Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells
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[PMID: 16759105] |
Glycyl-L-proline (17,22 μg/ml; 24 h) does not significantly affect cell viability in MCF-7 and MCF-7shPRODH/POX (knocked-down PRODH/POX) cells[1].
Glycyl-L-proline (17,22 μg/ml; 24 h) induces apoptosis in MCF-7 cells[1].
Glycyl-L-proline (17,22 μg/ml; 24 h) decreases collagen biosynthesis and DNA biosynthesis in MCF-7shPRODH/POX[1].
Glycyl-L-proline (10-50000 μM; 10 mins) decreases intracellular Gly-Sar uptake in Caco-2 cells with an IC50 of 257 µM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 and MCF-7shPRODH/POX
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Concentration:17,22 μg/ml
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Incubation Time:24 h
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Result:Showed no significant difference in cell viability between MCF-7 shPRODH/POX and MCF-7 control cells.
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Cell Line:MCF-7 and MCF-7shPRODH/POX
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Concentration:17,22 μg/ml
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Incubation Time:24 h
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Result:Decreased the expression of PRODH/POX, p53, Caspase 9 in MCF-7 cells.
Increased Caspase 3, cleaved Caspase 3, cleaved Caspase 9, iNOS, NF-κB, COX-2 and AMPKβ levels in MCF-7 cells.
Increased Caspase 9 levles in MCF-7shPRODH/POX cells.
Chemical Information
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No. CAS 704-15-4
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Appearance Solid
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Peso molecular 172.18
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Fòrmula C7H12N2O3
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Color White to off-white
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Synonyms
H-Gly-Pro-OH; Gly-Pro
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Redox Biol
ReDisulphID: A discovery platform for thiol redox sensors identifies a druggable site regulating p53 activation. [Abstract]2026 Jul:94:104196. PMID: 42097034
Solvente y solubilidad
H2O : 20 mg/mL (116.16 mM; ultrasonic and warming and heat to 60°C)
DMSO : 1 mg/mL (5.81 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Zareba I, et al. Proline oxidase silencing induces proline-dependent pro-survival pathways in MCF-7 cells. Oncotarget. 2018;9(17):13748-13757. Published 2018 Feb 9. [Content Brief]
[2]. von Linde T, et al. Rapid and Sensitive Quantification of Intracellular Glycyl-Sarcosine for Semi-High-Throughput Screening for Inhibitors of PEPT-1. Pharmaceutics. 2021;13(7):1019. Published 2021 Jul 3. [Content Brief]
[3]. Boyd CA, et al. L-proline transport by brush border membrane vesicles prepared from human placenta. J Physiol. 1981;315:9-19. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 5.8079 mL | 29.0394 mL | 58.0788 mL | 145.1969 mL |
| 5 mM | 1.1616 mL | 5.8079 mL | 11.6158 mL | 29.0394 mL | |
| H2O | 10 mM | 0.5808 mL | 2.9039 mL | 5.8079 mL | 14.5197 mL |
| 15 mM | 0.3872 mL | 1.9360 mL | 3.8719 mL | 9.6798 mL | |
| 20 mM | 0.2904 mL | 1.4520 mL | 2.9039 mL | 7.2598 mL | |
| 25 mM | 0.2323 mL | 1.1616 mL | 2.3232 mL | 5.8079 mL | |
| 30 mM | 0.1936 mL | 0.9680 mL | 1.9360 mL | 4.8399 mL | |
| 40 mM | 0.1452 mL | 0.7260 mL | 1.4520 mL | 3.6299 mL | |
| 50 mM | 0.1162 mL | 0.5808 mL | 1.1616 mL | 2.9039 mL | |
| 60 mM | 0.0968 mL | 0.4840 mL | 0.9680 mL | 2.4199 mL | |
| 80 mM | 0.0726 mL | 0.3630 mL | 0.7260 mL | 1.8150 mL | |
| 100 mM | 0.0581 mL | 0.2904 mL | 0.5808 mL | 1.4520 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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