1. Cell Cycle/DNA Damage
  2. Antifolate

Pralatrexate 

Cat. No.: HY-10446 Purity: 98.99%
Handling Instructions

Pralatrexate(Folotyn) is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines.

For research use only. We do not sell to patients.

Pralatrexate Chemical Structure

Pralatrexate Chemical Structure

CAS No. : 146464-95-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 218 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
5 mg USD 198 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 330 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 858 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Pralatrexate(Folotyn) is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines. IC50 Value: < 300 nM Target: Antifolate Pralatrexate is an antifolate (a folate analogue metabolic inhibitor) designed to accumulate preferentially in cancer cells. Based on preclinical studies, researchers believe that Pralatrexate selectively enters cells expressing reduced folate carrier type 1 (RFC-1), a protein that is overexpressed on certain cancer cells compared to normal cells.

Clinical Trial
References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.0944 mL 10.4719 mL 20.9437 mL
5 mM 0.4189 mL 2.0944 mL 4.1887 mL
10 mM 0.2094 mL 1.0472 mL 2.0944 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

477.47

Formula

C₂₃H₂₃N₇O₅

CAS No.

146464-95-1

SMILES

O=C(CC[[email protected]](NC(C1=CC=C(C=C1)C(CC#C)CC2=NC3=C(N=C(N=C3N=C2)N)N)=O)C(O)=O)O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 98.99%

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Product Name:
Pralatrexate
Cat. No.:
HY-10446
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