1. Cell Cycle/DNA Damage
    Apoptosis
  2. Antifolate
    Apoptosis
  3. Pralatrexate

Pralatrexate 

Cat. No.: HY-10446 Purity: 99.23%
Handling Instructions

Pralatrexate(Folotyn) is an antifolate, and structurally a folate analog.

For research use only. We do not sell to patients.

Pralatrexate Chemical Structure

Pralatrexate Chemical Structure

CAS No. : 146464-95-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 84 In-stock
Estimated Time of Arrival: December 31
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
50 mg USD 250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 450 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Publications Citing Use of MCE Pralatrexate

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Pralatrexate(Folotyn) is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines. IC50 Value: < 300 nM Target: Antifolate Pralatrexate is an antifolate (a folate analogue metabolic inhibitor) designed to accumulate preferentially in cancer cells. Based on preclinical studies, researchers believe that Pralatrexate selectively enters cells expressing reduced folate carrier type 1 (RFC-1), a protein that is overexpressed on certain cancer cells compared to normal cells.

Clinical Trial
Molecular Weight

477.47

Formula

C₂₃H₂₃N₇O₅

CAS No.

146464-95-1

SMILES

O=C(CC[[email protected]](NC(C1=CC=C(C=C1)C(CC#C)CC2=NC3=C(N=C(N=C3N=C2)N)N)=O)C(O)=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (104.72 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0944 mL 10.4719 mL 20.9437 mL
5 mM 0.4189 mL 2.0944 mL 4.1887 mL
10 mM 0.2094 mL 1.0472 mL 2.0944 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.24 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.24 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.23%

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

PralatrexateAntifolateApoptosisInhibitorinhibitorinhibit

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Pralatrexate
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HY-10446
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