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Cat. No.: HY-10446S1

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Pralatrexate-¹³C₅,¹⁵N

Pralatrexate-¹³C₅,¹⁵N is the ¹³C- and ¹⁵N-labeled Pralatrexate (HY-10446). Pralatrexate is an antifolate and is a potent dihydrofolate reductasean (DHFR) inhibitor with a K_i of 13.4 pM. Pralatrexate is a substrate for folylpolyglutamate synthetase with improved cellular uptake and retention. Pralatrexate has antitumor activities and has the potential for relapsed/refractory T-cell lymphoma treatment. Pralatrexate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Formula: C₁₈¹³C₅H₂₃N₆¹⁵NO₅
Molecular Weight:483.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Pralatrexate-¹³C₅,¹⁵N Chemical Structure

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Biological Activity
- Description
- In Vitro
- Application
Chemical Information
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Biological Activity

Description

Pralatrexate-¹³C₅,¹⁵N is the ¹³C- and ¹⁵N-labeled Pralatrexate (HY-10446). Pralatrexate is an antifolate and is a potent dihydrofolate reductasean (DHFR) inhibitor with a K_i of 13.4 pM. Pralatrexate is a substrate for folylpolyglutamate synthetase with improved cellular uptake and retention. Pralatrexate has antitumor activities and has the potential for relapsed/refractory T-cell lymphoma treatment^[1]^[2]^[3]^[4]. Pralatrexate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled Cas 146464-95-1
Molecular Weight 483.43
Formula C₁₈¹³C₅H₂₃N₆¹⁵NO₅
SMILES

O=[13C]([13CH2][13CH2][13C@H]([15NH]C(C1=CC=C(C=C1)C(CC#C)CC2=NC3=C(N=C(N=C3N=C2)N)N)=O)[13C](O)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.