2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Endogenous Metabolite Antifolate
  4. Folinic acid disodium

Folinic acid disodium  (Synonyms: Leucovorin disodium)

Cat. No.: HY-17556A
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Folinic acid (Leucovorin) disodium is a biological folic acid and is a forms of vitamin B9. Folinic acid disodium is generally administered along with Methotrexate (HY-14519) as a rescue agent to decrease MTX-induced toxicity. Folinic acid disodium and Sfluorouracil adjuvant chemotherapy shows effective in colon carcinoma.

For research use only. We do not sell to patients.

CAS No. : 163254-40-8

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Folinic acid disodium Related Antibodies

Top Publications Citing Use of Products

    Folinic acid disodium purchased from MedChemExpress. Usage Cited in: Int J Immunopathol Pharmacol. 2025 Jan-Dec:39:3946320251338662.  [Abstract]

    Effects of FOLFOX on surface PD-L1 expression on AGS cells. Cells were treated with FOLFOX (Leucovorin: 14 μM; 5-Fu: 200 μM; Oxaliplatin: 6 μM) for 48 h. Then, cells were co-stained with annexin V and PD-L1 antibody. Representative histogram showing surface PD-L1 expression. Red histogram: total cells. Purple histogram: annexin V-positive cells.

    Folinic acid disodium purchased from MedChemExpress. Usage Cited in: Int J Immunopathol Pharmacol. 2025 Jan-Dec:39:3946320251338662.  [Abstract]

    Effects of FOLFOX on surface MHC-I expression on AGS cells. Cells were treated with FOLFOX (Leucovorin: 14 μM; 5-Fu: 200 μM; Oxaliplatin: 6 μM) for 48 h. Then, cells were co-stained with annexin V and MHC-I antibody. Representative dot plots showing the expression of annexin V and surface MHC-I on AGS cells.

    Folinic acid disodium purchased from MedChemExpress. Usage Cited in: Virology. 2023 Aug:585:205-214.

    Leucovorin (10 μM; 48 h). VP1 protein levels were detected using Western blot.

    Folinic acid disodium purchased from MedChemExpress. Usage Cited in: Mol Oncol. 2020 Nov;14(11):2894-2919.  [Abstract]

    FOLFOX was administered as 6 mg/kg Oxaliplatin two hours before administration of 90 mg/kg Leucovorin and 50 mg/kg 5-Fluorouracil at day 1 and a repeat of 5‐Fluorouracil dosing on day 2. Weight loss of ODC-, CTRL-, and FOLFOX-treated mice over time of mice with DLD1 tumors.

    Folinic acid disodium purchased from MedChemExpress. Usage Cited in: Mol Oncol. 2020 Nov;14(11):2894-2919.  [Abstract]

    The corresponding panels show the activity of ODC, the corresponding monotherapy, and FOLFOX (0.5 µM Leucovorin, 5-Fluorouracil, Oxaliplatin), measured by comparing ATP levels in CRC cells (colored bars) and healthy CCD841 colonic epithelial cells (black bars) with CTRL (<0.15% DMSO), thus obtaining the treatment window (TW).

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    Description

    Folinic acid (Leucovorin) disodium is a biological folic acid and is a forms of vitamin B9. Folinic acid disodium is generally administered along with Methotrexate (HY-14519) as a rescue agent to decrease MTX-induced toxicity. Folinic acid disodium and Sfluorouracil adjuvant chemotherapy shows effective in colon carcinoma[1][2][3].

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    Folinic acid disodium (5, 50 μg/ml; 40 h) significantly reduces % micronucleated binucleated cells (MNBN) (40%-68%) and % aberrant cells (Abs) (36%-77%) in V79 cells that were treated with MTX at five different concentrations 5–100 mg/ml for 6 h[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Folinic acid disodium Related Antibodies
    In Vivo

    Folinic acid disodium (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following Methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)[2]
    Dosage: 7.0 mg/kg
    Administration: Intraperitoneal injection; every second day; for 3 weeks
    Result: Following MTX administration appears to reverse this growth inhibition.
    Molecular Weight

    517.40

    Formula

    C20H21N7Na2O7
    CAS No.
    SMILES

    O=C(O[Na])CC[C@@H](C(O[Na])=O)NC(C1=CC=C(NCC2N(C=O)C3=C(NC(N)=NC3=O)NC2)C=C1)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Folinic acid disodium Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Folinic acid disodium163254-40-8Leucovorin disodiumEndogenous MetaboliteAntifolateMTXvitamin B9colon carcinomaskeletal growthInhibitorinhibitorinhibit

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