5-Methyltetrahydrofolic acid-d₃  (Synonyms: 5-Methyl THF-d₃; 5-MTHF-d₃)

5-(Methyl-d₃)tetrahydrofolic Acid is the deuterium labeled 5-(Methyl)tetrahydrofolic Acid^[1].

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

462.47

C₂₀H₂₂D₃N₇O₆

1356019-97-0

134-35-0

Solid

White to light yellow

C(N1C2=C(NCC1CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)NC(N)=NC2=O)([2H])([2H])[2H]

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  [Content Brief]