γ-Aminobutyric acid-d6
Based on 2 publication(s) in Google Scholar
γ-Aminobutyric acid-d6 is the deuterium labeled γ-Aminobutyric acid. γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain, binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors).
For research use only. We do not sell to patients.
- Purity: 99.92%
- CAS No.: 70607-85-1
- Formula: C4H3D6NO2
- Molecular Weight:109.16
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) γ-Aminobutyric acid-d6
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 70607-85-1
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Unlabeled Cas 56-12-2
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Appearance Solid
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Molecular Weight 109.16
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Formula C4H3D6NO2
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Color White to off-white
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SMILES
OC(C([2H])([2H])C([2H])([2H])C([2H])([2H])N)=O
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Synonyms
4-Aminobutyric acid-d6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Inflammopharmacology
Evaluation of the antimigraine and anti-neuroinflammatory activity of purified constituents of Petasites hybridus L. in a migraine-like pain model in mice. [Abstract]2026 Feb;34(2):1159-1172. PMID: 41555115 -
J Pharm Biomed Anal
Validation and quantitation of six neurotransmitters in rat plasma and brain using liquid chromatography quadrupole-time-of-flight mass spectrometry. [Abstract]2025 Sep 8:267:117145. PMID: 40961653
Solvent & Solubility
H2O : 50 mg/mL (458.04 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Chen S, et al. Effects of dietary gamma-aminobutyric acid supplementation on the intestinal functions in weaning piglets. Food Funct. 2019 Jan 2. [Content Brief]
[3]. Okada R, et al. Gamma-aminobutyric acid (GABA)-mediated neural connections in the Drosophila antennal lobe. J Comp Neurol. 2009 May 1;514(1):74-91. [Content Brief]
[4]. Watanabe M, et al. GABA and GABA receptors in the central nervous system and other organs. Int Rev Cytol. 2002;213:1-47. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 9.1609 mL | 45.8043 mL | 91.6086 mL | 229.0216 mL |
| 5 mM | 1.8322 mL | 9.1609 mL | 18.3217 mL | 45.8043 mL | |
| 10 mM | 0.9161 mL | 4.5804 mL | 9.1609 mL | 22.9022 mL | |
| 15 mM | 0.6107 mL | 3.0536 mL | 6.1072 mL | 15.2681 mL | |
| 20 mM | 0.4580 mL | 2.2902 mL | 4.5804 mL | 11.4511 mL | |
| 25 mM | 0.3664 mL | 1.8322 mL | 3.6643 mL | 9.1609 mL | |
| 30 mM | 0.3054 mL | 1.5268 mL | 3.0536 mL | 7.6341 mL | |
| 40 mM | 0.2290 mL | 1.1451 mL | 2.2902 mL | 5.7255 mL | |
| 50 mM | 0.1832 mL | 0.9161 mL | 1.8322 mL | 4.5804 mL | |
| 60 mM | 0.1527 mL | 0.7634 mL | 1.5268 mL | 3.8170 mL | |
| 80 mM | 0.1145 mL | 0.5726 mL | 1.1451 mL | 2.8628 mL | |
| 100 mM | 0.0916 mL | 0.4580 mL | 0.9161 mL | 2.2902 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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