N-Acetyl-L-aspartic acid-d3
Based on 1 Customer Validation
N-Acetyl-L-aspartic acid-d3 is the deuterium labeled N-Acetyl-L-aspartic acid (HY-113524). N-Acetyl-L-aspartic acid is a derivative of Aspartic acid (HY-N0666) and endogenous compound. N-Acetyl-L-aspartic acid acts as an acetyl donor. N-Acetyl-L-aspartic acid is involved in brain metabolism. N-Acetyl-L-aspartic acid is used in the research of neurodegenerative diseases (such as Canavan disease).
For research use only. We do not sell to patients.
- Purity: 99.77%
- CAS No.: 284665-15-2
- Formula: C6H6D3NO5
- Molecular Weight:178.16
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 284665-15-2
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Unlabeled Cas 997-55-7
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Appearance Solid
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Molecular Weight 178.16
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Formula C6H6D3NO5
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Color White to off-white
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SMILES
O=C(O)C([2H])([2H])C(C(O)=O)([2H])NC(C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 62.5 mg/mL (350.81 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Buniatian HC, et al. The participation of N-acetyl-L-aspartic acid in brain metabolism. J Neurochem. 1965 Aug;12(8):695-703. [Content Brief]
[2]. Sreekumar A, et al. Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. [Content Brief]
[3]. Karaman S, et al. Subchronic oral toxicity assessment of N-acetyl-L-aspartic acid in rats. Food Chem Toxicol. 2011 Jan;49(1):155-65. [Content Brief]
[4]. Karaman S, et al. Two-generation reproductive and developmental toxicity assessment of dietary N-acetyl-L-aspartic acid in rats. Food Chem Toxicol. 2011 Dec;49(12):3192-205. [Content Brief]
[5]. Delaney B, et al. Acute and repeated dose oral toxicity of N-acetyl-l-aspartic acid in Sprague-Dawley rats. Food Chem Toxicol. 2008 Jun;46(6):2023-34. [Content Brief]
[6]. Birken DL, et al. N-acetyl-L-aspartic acid: a literature review of a compound prominent in 1H-NMR spectroscopic studies of brain. Neurosci Biobehav Rev. 1989 Spring;13(1):23-31. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.6129 mL | 28.0647 mL | 56.1293 mL | 140.3233 mL |
| 5 mM | 1.1226 mL | 5.6129 mL | 11.2259 mL | 28.0647 mL | |
| 10 mM | 0.5613 mL | 2.8065 mL | 5.6129 mL | 14.0323 mL | |
| 15 mM | 0.3742 mL | 1.8710 mL | 3.7420 mL | 9.3549 mL | |
| 20 mM | 0.2806 mL | 1.4032 mL | 2.8065 mL | 7.0162 mL | |
| 25 mM | 0.2245 mL | 1.1226 mL | 2.2452 mL | 5.6129 mL | |
| 30 mM | 0.1871 mL | 0.9355 mL | 1.8710 mL | 4.6774 mL | |
| 40 mM | 0.1403 mL | 0.7016 mL | 1.4032 mL | 3.5081 mL | |
| 50 mM | 0.1123 mL | 0.5613 mL | 1.1226 mL | 2.8065 mL | |
| 60 mM | 0.0935 mL | 0.4677 mL | 0.9355 mL | 2.3387 mL | |
| 80 mM | 0.0702 mL | 0.3508 mL | 0.7016 mL | 1.7540 mL | |
| 100 mM | 0.0561 mL | 0.2806 mL | 0.5613 mL | 1.4032 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
N-Acetyl-L-aspartic acid-d3 Related Classifications
HY-113524S Related Classifications
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