L-Glutamine-d5
Based on 1 publication(s) in Google Scholar
L-Glutamine-d5 is the deuterium labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na+-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity.
For research use only. We do not sell to patients.
- Purity: 99.79%
- CAS No.: 14341-78-7
- Formula: C5H5D5N2O3
- Molecular Weight:151.18
-
Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) L-Glutamine-d5
MoreAll Endogenous Metabolite Isoforms
More
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
CAS No. 14341-78-7
-
Unlabeled Cas 56-85-9
-
Appearance Solid
-
Molecular Weight 151.18
-
Formula C5H5D5N2O3
-
Color White to off-white
-
SMILES
NC(C([2H])([2H])C([2H])([2H])[C@@](N)([2H])C(O)=O)=O
-
Synonyms
L-Glutamic acid 5-amide-d5
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
-
Journal Impact Factor
-
Most Recent
Solvent & Solubility
H2O : 12.5 mg/mL (82.68 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (277 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Zhou T, et al. Glutamine Metabolism Is Essential for Stemness of Bone Marrow Mesenchymal Stem Cells and Bone Homeostasis. Stem Cells Int. 2019;2019:8928934. Published 2019 Sep 12. [Content Brief]
[3]. Luo LL, et al. L-glutamine protects mouse brain from ischemic injury via up-regulating heat shock protein 70. CNS Neurosci Ther. 2019;25(9):1030-1041. [Content Brief]
[4]. Shao H, et al. The protective effect of L-glutamine against acute Cantharidin-induced Cardiotoxicity in the mice. BMC Pharmacol Toxicol. 2020;21(1):71. Published 2020 Oct 1. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 6.6146 mL | 33.0732 mL | 66.1463 mL | 165.3658 mL |
| 5 mM | 1.3229 mL | 6.6146 mL | 13.2293 mL | 33.0732 mL | |
| 10 mM | 0.6615 mL | 3.3073 mL | 6.6146 mL | 16.5366 mL | |
| 15 mM | 0.4410 mL | 2.2049 mL | 4.4098 mL | 11.0244 mL | |
| 20 mM | 0.3307 mL | 1.6537 mL | 3.3073 mL | 8.2683 mL | |
| 25 mM | 0.2646 mL | 1.3229 mL | 2.6459 mL | 6.6146 mL | |
| 30 mM | 0.2205 mL | 1.1024 mL | 2.2049 mL | 5.5122 mL | |
| 40 mM | 0.1654 mL | 0.8268 mL | 1.6537 mL | 4.1341 mL | |
| 50 mM | 0.1323 mL | 0.6615 mL | 1.3229 mL | 3.3073 mL | |
| 60 mM | 0.1102 mL | 0.5512 mL | 1.1024 mL | 2.7561 mL | |
| 80 mM | 0.0827 mL | 0.4134 mL | 0.8268 mL | 2.0671 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
L-Glutamine-d5 Related Classifications
HY-N0390S2 Related Classifications
Powered by Bioz