4-Hydroxyphenylacetic acid-d6
Based on 1 Customer Validation
4-Hydroxyphenylacetic acid-d6 is the deuterium labeled 4-Hydroxyphenylacetic acid. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2.
For research use only. We do not sell to patients.
- Purity: 99.16%
- CAS No.: 100287-06-7
- Formula: C8H2D6O3
- Molecular Weight:158.18
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 100287-06-7
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Unlabeled Cas 156-38-7
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Appearance Solid
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Molecular Weight 158.18
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Formula C8H2D6O3
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Color Off-white to pink
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SMILES
OC(C([2H])([2H])C1=C([2H])C([2H])=C(C([2H])=C1[2H])O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (632.19 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Zhao H, et al. 4-Hydroxyphenylacetic Acid Prevents Acute APAP-Induced Liver Injury by Increasing Phase IIand Antioxidant Enzymes in Mice. Front Pharmacol. 2018 Jun 19;9:653. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.3219 mL | 31.6096 mL | 63.2191 mL | 158.0478 mL |
| 5 mM | 1.2644 mL | 6.3219 mL | 12.6438 mL | 31.6096 mL | |
| 10 mM | 0.6322 mL | 3.1610 mL | 6.3219 mL | 15.8048 mL | |
| 15 mM | 0.4215 mL | 2.1073 mL | 4.2146 mL | 10.5365 mL | |
| 20 mM | 0.3161 mL | 1.5805 mL | 3.1610 mL | 7.9024 mL | |
| 25 mM | 0.2529 mL | 1.2644 mL | 2.5288 mL | 6.3219 mL | |
| 30 mM | 0.2107 mL | 1.0537 mL | 2.1073 mL | 5.2683 mL | |
| 40 mM | 0.1580 mL | 0.7902 mL | 1.5805 mL | 3.9512 mL | |
| 50 mM | 0.1264 mL | 0.6322 mL | 1.2644 mL | 3.1610 mL | |
| 60 mM | 0.1054 mL | 0.5268 mL | 1.0537 mL | 2.6341 mL | |
| 80 mM | 0.0790 mL | 0.3951 mL | 0.7902 mL | 1.9756 mL | |
| 100 mM | 0.0632 mL | 0.3161 mL | 0.6322 mL | 1.5805 mL |
4-Hydroxyphenylacetic acid-d6 Related Classifications
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