1. NF-κB
  2. Keap1-Nrf2

4-Hydroxyphenylacetic acid 

Cat. No.: HY-N1902 Purity: >98.0%
Handling Instructions

4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2.

For research use only. We do not sell to patients.

4-Hydroxyphenylacetic acid Chemical Structure

4-Hydroxyphenylacetic acid Chemical Structure

CAS No. : 156-38-7

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2[1].

IC50 & Target

Nrf2[1]

In Vivo

4-Hydroxyphenylacetic acid (6, 12, or 25 mg/kg) increases Nrf2 translocation to the nucleus and enhances the activity of phase II and antioxidant enzymes. The protein levels of nuclear Nrf2 are increased by 170% and 230% in pre-treated 12 and 25 mg/kg 4-Hydroxyphenylacetic acid groups, respectively, compared with the control group.The 4-Hydroxyphenylacetic acid pretreatment at a final dose of 25 mg/kg markedly and selectively up-regulated the target genes of phase II enzymes and resulted in higher up-regulation than that of the control group by 270%, 400%, and 500% or UGT1A1, UGT1A9, and SULT2A1, respectively. 4-Hydroxyphenylacetic acid also suppresses the expression of CYP2E1[1].

References
Molecular Weight

152.15

Formula

C₈H₈O₃

CAS No.

156-38-7

SMILES

O=C(O)CC1=CC=C(O)C=C1

Storage

4°C, stored under nitrogen

Shipping

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

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Product Name:
4-Hydroxyphenylacetic acid
Cat. No.:
HY-N1902
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4-Hydroxyphenylacetic acid

Cat. No.: HY-N1902