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4-Hydroxyphenylacetic acid (Standard)

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4-Hydroxyphenylacetic acid (Standard) is the analytical standard of 4-Hydroxyphenylacetic acid. This product is intended for research and analytical applications. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2. IC50 & Target:Nrf2 In Vivo: 4-Hydroxyphenylacetic acid (6, 12, or 25 mg/kg) increases Nrf2 translocation to the nucleus and enhances the activity of phase II and antioxidant enzymes. The protein levels of nuclear Nrf2 are increased by 170% and 230% in pre-treated 12 and 25 mg/kg 4-Hydroxyphenylacetic acid groups, respectively, compared with the control group.The 4-Hydroxyphenylacetic acid pretreatment at a final dose of 25 mg/kg markedly and selectively up-regulated the target genes of phase II enzymes and resulted in higher up-regulation than that of the control group by 270%, 400%, and 500% or UGT1A1, UGT1A9, and SULT2A1, respectively. 4-Hydroxyphenylacetic acid also suppresses the expression of CYP2E1.

For research use only. We do not sell to patients.

  • Purity: 99.24%
  • CAS No.: 156-38-7
  • Formula: C8H8O3
  • Molecular Weight:152.15
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • 4-Hydroxyphenylacetic acid (Standard) Chemical Structure
    4-Hydroxyphenylacetic acid (Standard) Chemical Structure
CAS No.: 156-38-7
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  • 4-Hydroxyphenylacetic acid (Standard) Chemical Structure
    4-Hydroxyphenylacetic acid (Standard) Chemical Structure
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  • 4-Hydroxyphenylacetic acid (Standard)