2. Anti-infection Metabolic Enzyme/Protease
  3. Influenza Virus Endogenous Metabolite
  4. Desaminotyrosine

Desaminotyrosine  (Synonyms: 3-(4-Hydroxyphenyl)propionic acid)

Cat. No.: HY-W015346 Purity: 99.81%
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Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling.

For research use only. We do not sell to patients.

CAS No. : 501-97-3

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Desaminotyrosine:

Desaminotyrosine Related Antibodies

Top Publications Citing Use of Products
Cell Proliferation/Viability Assay
IF
RT-PCR
ELISA
Flow Cytometry

    Desaminotyrosine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jun;12(21):e2417827.  [Abstract]

    Cell viability measured by Alamar blue staining of NRVMs (left panel) and LDH (lactate dehydrogenase) release from NRVMs (right panel) in the presence or absence of Desaminotyrosine (DAT) (100 μM) under normoxic and OGD/R conditions.

    Desaminotyrosine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jun;12(21):e2417827.  [Abstract]

    DHE staining in heart sections from Sham, I/R, and I/R+ Desaminotyrosine (DAT) (100 μM) groups.

    Desaminotyrosine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jun;12(21):e2417827.  [Abstract]

    qRT‐PCR analysis showing the mRNA levels of Il6 and Tnf in BMDMs Desaminotyrosine (DAT) (100 μM).

    Desaminotyrosine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jun;12(21):e2417827.  [Abstract]

    ELISA showing the secretion of IL‐6 and TNF‐α by BMDMs treated with Desaminotyrosine (DAT) (100 μM).

    Desaminotyrosine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jun;12(21):e2417827.  [Abstract]

    Schematic diagram (left panel) and flow cytometry analysis of DHE‐positive BMDMs stimulated with Sham lysate and I/R lysate for 24 h with or without Desaminotyrosine (DAT) pretreatment at 100 µM (right panel).

    View All Endogenous Metabolite Isoform Specific Products:

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    Human Endogenous Metabolite Microbial Metabolite

    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling.

    IC50 & Target

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    In Vivo

    Wild-type mice produce nanomoles of Desaminotyrosine per gram of feces and have picomolar quantities of Desaminotyrosine in the serum. Desaminotyrosine (200 mM) treatment before influenza infection, protects from influenza by type I interferon (IFN) signaling, with no effect on weight loss or survival in mice with or without vancomycin, neomycin, ampicillin, and metronidazole (VNAM). Desaminotyrosine enhances type I IFN in macrophages via type I IFN amplification in mice[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    166.18

    Formula

    C9H10O3
    CAS No.
    Appearance

    Solid

    Color

    White to light brown

    SMILES

    C1=C(C=CC(=C1)O)CCC(O)=O
    Structure Classification
    Initial Source

    Saccharomyces cerevisiae
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (601.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 33.33 mg/mL (200.57 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 6.0177 mL 30.0886 mL 60.1772 mL
    5 mM 1.2035 mL 6.0177 mL 12.0354 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

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    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (15.04 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (15.04 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (601.77 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.90%

    SDS (393 KB)

    COA (244 KB) HNMR (130 KB) RP-HPLC (266 KB)

    Handling Instructions (2659 KB)
    References
    Animal Administration
    [1]

    Mice[1]
    Indicated mice receive 200 mM Desaminotyrosine dissolved in Kool-Aid in the drinking water (control animals receive Kool-Aid alone). Indicated mice receive poly(IC) injections of 1 mg/kg for vancomycin, neomycin, ampicillin, and metronidazole (VNAM) treated mice or 5 mg/kg for all other mice intraperitoneally daily for 4 days, and then mice are scarified on day five at which time serum is collected[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 6.0177 mL 30.0886 mL 60.1772 mL 150.4429 mL
    5 mM 1.2035 mL 6.0177 mL 12.0354 mL 30.0886 mL
    10 mM 0.6018 mL 3.0089 mL 6.0177 mL 15.0443 mL
    15 mM 0.4012 mL 2.0059 mL 4.0118 mL 10.0295 mL
    20 mM 0.3009 mL 1.5044 mL 3.0089 mL 7.5221 mL
    25 mM 0.2407 mL 1.2035 mL 2.4071 mL 6.0177 mL
    30 mM 0.2006 mL 1.0030 mL 2.0059 mL 5.0148 mL
    40 mM 0.1504 mL 0.7522 mL 1.5044 mL 3.7611 mL
    50 mM 0.1204 mL 0.6018 mL 1.2035 mL 3.0089 mL
    60 mM 0.1003 mL 0.5015 mL 1.0030 mL 2.5074 mL
    80 mM 0.0752 mL 0.3761 mL 0.7522 mL 1.8805 mL
    100 mM 0.0602 mL 0.3009 mL 0.6018 mL 1.5044 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Desaminotyrosine Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Desaminotyrosine501-97-33-(4-Hydroxyphenyl)propionic acidInfluenza VirusEndogenous MetaboliteInhibitorinhibitorinhibit

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