Cat. No.: HY-W015346

Desaminotyrosine

(Synonyms: 3-(4-Hydroxyphenyl)propionic acid)

3 Cited Publications

Customer Review

Based on 3 publication(s) in Google Scholar

Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling.

For research use only. We do not sell to patients.

Purity: 99.81%
CAS No.: 501-97-3
Formula: C₉H₁₀O₃
Molecular Weight:166.18

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Desaminotyrosine Chemical Structure

CAS No.: 501-97-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (3)
Solvent & Solubility
- In Vitro
- In Vivo
Protocol
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling.

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

In Vivo

Wild-type mice produce nanomoles of Desaminotyrosine per gram of feces and have picomolar quantities of Desaminotyrosine in the serum. Desaminotyrosine (200 mM) treatment before influenza infection, protects from influenza by type I interferon (IFN) signaling, with no effect on weight loss or survival in mice with or without vancomycin, neomycin, ampicillin, and metronidazole (VNAM). Desaminotyrosine enhances type I IFN in macrophages via type I IFN amplification in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 501-97-3
Appearance Solid
Molecular Weight 166.18
Formula C₉H₁₀O₃
Color White to light brown
SMILES

C1=C(C=CC(=C1)O)CCC(O)=O
Synonyms

3-(4-Hydroxyphenyl)propionic acid
Structure Classification
- Phenols
- Monophenols
- Ketones, Aldehydes, Acids
Initial Source
- Microorganisms
- Endogenous metabolite
Saccharomyces cerevisiae
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (3)

All Cell Proliferation/Viability AssayIFRT-PCRELISAFlow Cytometry

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Journal Impact Factor

Adv Sci (Weinh)

Flavonifractor Plautii or Its Metabolite Desaminotyrosine as Prophylactic Agents for Alleviating Myocardial Ischemia/Reperfusion Injury. [Abstract]

2025 Jun;12(21):e2417827. PMID: 40089859

Desaminotyrosine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jun;12(21):e2417827. [Abstract]

Cell viability measured by Alamar blue staining of NRVMs (left panel) and LDH (lactate dehydrogenase) release from NRVMs (right panel) in the presence or absence of Desaminotyrosine (DAT) (100 μM) under normoxic and OGD/R conditions.

Desaminotyrosine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jun;12(21):e2417827. [Abstract]

DHE staining in heart sections from Sham, I/R, and I/R+ Desaminotyrosine (DAT) (100 μM) groups.

Desaminotyrosine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jun;12(21):e2417827. [Abstract]

qRT‐PCR analysis showing the mRNA levels of Il6 and Tnf in BMDMs Desaminotyrosine (DAT) (100 μM).

Desaminotyrosine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jun;12(21):e2417827. [Abstract]

ELISA showing the secretion of IL‐6 and TNF‐α by BMDMs treated with Desaminotyrosine (DAT) (100 μM).

Desaminotyrosine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jun;12(21):e2417827. [Abstract]

Schematic diagram (left panel) and flow cytometry analysis of DHE‐positive BMDMs stimulated with Sham lysate and I/R lysate for 24 h with or without Desaminotyrosine (DAT) pretreatment at 100 µM (right panel).
Clin Immunol

Short-chain fatty acid deficiency drives aberrant B cell differentiation in systemic lupus erythematosus. [Abstract]

2026 Jun:285:110706. PMID: 41974394
Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (601.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 33.33 mg/mL (200.57 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.0177 mL

30.0886 mL

60.1772 mL

5 mM

1.2035 mL

6.0177 mL

12.0354 mL

10 mM

0.6018 mL

3.0089 mL

6.0177 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (15.04 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (15.04 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (15.04 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (601.77 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Protocol

Animal Administration^[1]

Mice^[1]
Indicated mice receive 200 mM Desaminotyrosine dissolved in Kool-Aid in the drinking water (control animals receive Kool-Aid alone). Indicated mice receive poly(IC) injections of 1 mg/kg for vancomycin, neomycin, ampicillin, and metronidazole (VNAM) treated mice or 5 mg/kg for all other mice intraperitoneally daily for 4 days, and then mice are scarified on day five at which time serum is collected^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Steed AL, et al. The microbial metabolite desaminotyrosine protects from influenza through type I interferon. Science. 2017 Aug 4;357(6350):498-502. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	6.0177 mL	30.0886 mL	60.1772 mL	150.4429 mL
	5 mM	1.2035 mL	6.0177 mL	12.0354 mL	30.0886 mL
	10 mM	0.6018 mL	3.0089 mL	6.0177 mL	15.0443 mL
	15 mM	0.4012 mL	2.0059 mL	4.0118 mL	10.0295 mL
	20 mM	0.3009 mL	1.5044 mL	3.0089 mL	7.5221 mL
	25 mM	0.2407 mL	1.2035 mL	2.4071 mL	6.0177 mL
	30 mM	0.2006 mL	1.0030 mL	2.0059 mL	5.0148 mL
	40 mM	0.1504 mL	0.7522 mL	1.5044 mL	3.7611 mL
	50 mM	0.1204 mL	0.6018 mL	1.2035 mL	3.0089 mL
	60 mM	0.1003 mL	0.5015 mL	1.0030 mL	2.5074 mL
	80 mM	0.0752 mL	0.3761 mL	0.7522 mL	1.8805 mL
	100 mM	0.0602 mL	0.3009 mL	0.6018 mL	1.5044 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Desaminotyrosine

3 Cited Publications

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Desaminotyrosine

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Publications Citing Use of MedChemExpress (MCE) Desaminotyrosine

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Publications (3)

Solvent & Solubility

Protocol

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Desaminotyrosine Related Classifications

HY-W015346 Related Classifications