1. Anti-infection
    Metabolic Enzyme/Protease
  2. Influenza Virus
    Endogenous Metabolite
  3. Desaminotyrosine

Desaminotyrosine (Synonyms: 3-(4-Hydroxyphenyl)propionic acid)

Cat. No.: HY-W015346 Purity: 99.32%
Handling Instructions

Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling.

For research use only. We do not sell to patients.

Desaminotyrosine Chemical Structure

Desaminotyrosine Chemical Structure

CAS No. : 501-97-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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  • Biological Activity

  • Protocol

  • Technical Information

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Description

Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling.

IC50 & Target

Type I interferon, Influenza virus[1]

In Vivo

Wild-type mice produce nanomoles of Desaminotyrosine per gram of feces and have picomolar quantities of Desaminotyrosine in the serum. Desaminotyrosine (200 mM) treatment before influenza infection, protects from influenza by type I interferon (IFN) signaling, with no effect on weight loss or survival in mice with or without vancomycin, neomycin, ampicillin, and metronidazole (VNAM). Desaminotyrosine enhances type I IFN in macrophages via type I IFN amplification in mice[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 300 mg/mL (1805.27 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.0176 mL 30.0879 mL 60.1757 mL
5 mM 1.2035 mL 6.0176 mL 12.0351 mL
10 mM 0.6018 mL 3.0088 mL 6.0176 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Mice[1]
Indicated mice receive 200 mM Desaminotyrosine dissolved in Kool-Aid in the drinking water (control animals receive Kool-Aid alone). Indicated mice receive poly(IC) injections of 1 mg/kg for vancomycin, neomycin, ampicillin, and metronidazole (VNAM) treated mice or 5 mg/kg for all other mice intraperitoneally daily for 4 days, and then mice are scarified on day five at which time serum is collected[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

166.18

Formula

C₉H₁₀O₃

CAS No.

501-97-3

SMILES

C1=C(C=CC(=C1)O)CCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.32%

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Desaminotyrosine
Cat. No.:
HY-W015346
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Desaminotyrosine

Cat. No.: HY-W015346