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Cat. No.: HY-N8472

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Chrodrimanin B

Chrodrimanin B, a metabolite of a fungal, is a potent, non-open-channel-blocking antagonist on?B.?mori GABAR RDL with an IC₅₀?of 1.13 nM. Chrodrimanin B attenuates the peak current amplitude of the GABA response of RDL with an IC₅₀?of 1.66 nM.?Chrodrimanin B, a meroterpenoid, shows insecticidal activity.

For research use only. We do not sell to patients.

CAS No.: 132196-54-4
Formula: C₂₇H₃₂O₈
Molecular Weight:484.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Chrodrimanin B Chemical Structure

CAS No.: 132196-54-4

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Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>50 μM Compound: 5	Cytotoxicity against human A549 cells by sulforhodamine B assay Cytotoxicity against human A549 cells by sulforhodamine B assay	[PMID: 26046820]
HeLa	IC₅₀	>50 μM Compound: 5	Cytotoxicity against human HeLa cells by sulforhodamine B assay Cytotoxicity against human HeLa cells by sulforhodamine B assay	[PMID: 26046820]
HL-60	IC₅₀	>50 μM Compound: 5	Cytotoxicity against human HL60 cells by sulforhodamine B assay Cytotoxicity against human HL60 cells by sulforhodamine B assay	[PMID: 26046820]
K562	IC₅₀	>50 μM Compound: 5	Cytotoxicity against human K562 cells by sulforhodamine B assay Cytotoxicity against human K562 cells by sulforhodamine B assay	[PMID: 26046820]
MDCK	IC₅₀	55 μM Compound: 5	Antiviral activity against influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in MDCK cells incubated for 48 hrs assessed as inhibition of virus-induced cytopathic effect by crystal violet staining assay Antiviral activity against influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in MDCK cells incubated for 48 hrs assessed as inhibition of virus-induced cytopathic effect by crystal violet staining assay	[PMID: 26046820]

In Vitro

Chrodrimanin B exhibits much weaker blocking action on human α1β2γ2 GABAR compared to RDL (IC₅₀=1.48 μM)^[1].
Chrodrimanin B shows competitive actions at low concentrations and non-competitive actions at higher concentrations on?B.?mori GABAR RDL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 132196-54-4
Molecular Weight 484.54
Formula C₂₇H₃₂O₈
SMILES

C[C@@]([C@@](C(C)1C)([H])C[C@@H]2O)(C=CC1=O)[C@@](CC3=C([C@H]([C@H]4C)OC(C)=O)C(C(O4)=O)=C5O)([H])[C@]2(OC3=C5)C
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Microorganisms
Aspergillus sp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yan Xu, et al. Meroterpenoid Chrodrimanins Are Selective and Potent Blockers of Insect GABA-Gated Chloride Channels. PLoS One. 2015 Apr 22;10(4):e0122629. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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