Chrodrimanins I and J from the Antarctic Moss-Derived Fungus Penicillium funiculosum GWT2-24

  • J Nat Prod. 2015 Jun 26;78(6):1442-5. doi: 10.1021/acs.jnatprod.5b00103.
Haibo Zhou  1 ,  Liyuan Li  1 ,  Wei Wang  1 ,  Qian Che  1 ,  Dehai Li  1 ,  Qianqun Gu  1 ,  Tianjiao Zhu  1
Affiliations
  • 1. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
PMID: 26046820 DOI: 10.1021/acs.jnatprod.5b00103
Abstract

Two new meroterpenoids, named chrodrimanins I and J (1 and 2), together with five known biosynthetically related chrodrimanins (3-7), were isolated from the culture of the Antarctic moss-derived fungus Penicillium funiculosum GWT2-24. Distinguished from all of the reported chrodrimanins, compounds 1 and 2 possess a unique cyclohexanone (E ring) instead of a δ-lactone ring. These structures including the absolute configurations were established on the basis of MS, NMR, and X-ray crystallographic analysis. Compounds 1-7 showed no cytotoxic or Antibacterial activities, while the known compounds 3, 5, and 6 exhibited inhibitory activities against Influenza Virus A (H1N1), with IC50 values ranged from 21 to 57 μM.