DBCO-PEG4-VC-PAB-DMEA-PNU-159682

Name: DBCO-PEG4-VC-PAB-DMEA-PNU-159682
Brand: MedChemExpress
SKU: HY-126691
Rating: 4.5 (0 reviews)

製品番号: HY-126691 純度: 99.03%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

DBCO-PEG4-VC-PAB-DMEA-PNU-159682, a agent-linker conjugate for ADC, consists the ADC linker DBCO-PEG4-VC-PAB and a potent ADC cytotoxin DMEA-PNU-159682. DMEA-PNU-159682 includes metabolites of nemorubicin (MMDX) from liver microsomes and ADC cytotoxin PNU-159682. DBCO-PEG4-VC-PAB-DMEA-PNU-159682 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

DBCO-PEG4-VC-PAB-DMEA-PNU-159682 構造式

CAS 番号 : 2259318-56-2

容量	価格（税別）	在庫状況	数量
1 mg	$1920	在庫あり	Estimated Time of Arrival: December 31
5 mg		お問い合わせ
10 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Drug-Linker Conjugates for ADC アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target

Duocarmycins

体外実験

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1695.81

分子式

C₈₆H₁₀₆N₁₀O₂₆

CAS 番号

2259318-56-2

Appearance

Solid

Color

Orange to red

SMILES

C[C@H]1[C@]2([H])[C@](N3[C@]([C@H](OCC3)OC)([H])O2)([H])C[C@](O1)([H])O[C@@H]4C5=C(C[C@](C(COC(N(C)CCN(C)C(OCC6=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCC(NCCC(N7C8=CC=CC=C8C#CC9=CC=CC=C9C7)=O)=O)=O)=O)=O)C=C6)=O)=O)=O)(O)C4)C(O)=C%10C(C(C%11=C(OC)C=CC=C%11C%10=O)=O)=C5O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (58.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.5897 mL	2.9484 mL	5.8969 mL
5 mM	0.1179 mL	0.5897 mL	1.1794 mL
10 mM	0.0590 mL	0.2948 mL	0.5897 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.03%

Select Batch:

データシート (275 KB) SDS (252 KB)

COA (254 KB) HNMR (421 KB) RP-HPLC (229 KB) LCMS (100 KB)

取扱説明書 (2659 KB)

参考文献

[1]. John Flygare, et al. Anthracycline disulfide intermediates, antibody-drug conjugates and methods. WO2016040825A1

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.5897 mL	2.9484 mL	5.8969 mL	14.7422 mL
	5 mM	0.1179 mL	0.5897 mL	1.1794 mL	2.9484 mL
	10 mM	0.0590 mL	0.2948 mL	0.5897 mL	1.4742 mL
	15 mM	0.0393 mL	0.1966 mL	0.3931 mL	0.9828 mL
	20 mM	0.0295 mL	0.1474 mL	0.2948 mL	0.7371 mL
	25 mM	0.0236 mL	0.1179 mL	0.2359 mL	0.5897 mL
	30 mM	0.0197 mL	0.0983 mL	0.1966 mL	0.4914 mL
	40 mM	0.0147 mL	0.0737 mL	0.1474 mL	0.3686 mL
	50 mM	0.0118 mL	0.0590 mL	0.1179 mL	0.2948 mL