1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. DBCO-PEG4-Val-Cit-PAB-MMAF

DBCO-PEG4-Val-Cit-PAB-MMAF 

Cat. No.: HY-130990
Handling Instructions

DBCO-PEG4-Val-Cit-PAB-MMAF consists a cleavable 4 unit PEG ADC linker (DBCO-PEG4-Val-Cit-PAB) and a potent tubulin polymerization inhibitor (MMAF). DBCO-PEG4-Val-Cit-PAB-MMAF can be used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

DBCO-PEG4-Val-Cit-PAB-MMAF Chemical Structure

DBCO-PEG4-Val-Cit-PAB-MMAF Chemical Structure

CAS No. : 2244602-23-9

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Description

DBCO-PEG4-Val-Cit-PAB-MMAF consists a cleavable 4 unit PEG ADC linker (DBCO-PEG4-Val-Cit-PAB) and a potent tubulin polymerization inhibitor (MMAF). DBCO-PEG4-Val-Cit-PAB-MMAF can be used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target

Auristatin

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

Molecular Weight

1672.01

Formula

C₈₈H₁₂₆N₁₂O₂₀

CAS No.

2244602-23-9

SMILES

C[[email protected]@H](C(N[[email protected]](C(O)=O)CC1=CC=CC=C1)=O)[[email protected]]([[email protected]@](CCC2)([H])N2C(C[[email protected]@H](OC)[[email protected]@]([[email protected]@H](C)CC)([H])N(C)C([[email protected]](C(C)C)NC([[email protected]](C(C)C)N(C)C(OCC3=CC=C(NC([[email protected]](CCCNC(N)=O)NC([[email protected]@H](NC(CCOCCOCCOCCOCCNC(CCC(N4C(C=CC=C5)=C5C#CC(C=CC=C6)=C6C4)=O)=O)=O)C(C)C)=O)=O)C=C3)=O)=O)=O)=O)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

DBCO-PEG4-Val-Cit-PAB-MMAFDrug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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DBCO-PEG4-Val-Cit-PAB-MMAF
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HY-130990
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