2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. MC-Val-Cit-PAB-MMAF

MC-Val-Cit-PAB-MMAF  (Synonyms: Vc-MMAF)

Cat. No.: HY-112786 Purity: 99.25%
COA
SDS
Handling Instructions Technical Support

MC-Val-Cit-PAB-MMAF (Vc-MMAF) is a drug-linker conjugate for ADC by using the tubulin inhibitor, MMAF (HY-15579), linked via cathepsin cleavable MC-Val-Cit-PAB (HY-78738). MC-Val-Cit-PAB-MMAF shows antitumor activity.

For research use only. We do not sell to patients.

CAS No. : 863971-17-9

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Customer Review

Based on 5 publication(s) in Google Scholar

MC-Val-Cit-PAB-MMAF Related Antibodies

Top Publications Citing Use of Products

    MC-Val-Cit-PAB-MMAF purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jan 24;17(1):162.  [Abstract]

    MC-Val-Cit-PAB-MMAF (ADC-MMAF) (50 nM; 72 h) effectively killed A375 WT cells.

    MC-Val-Cit-PAB-MMAF purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jan 24;17(1):162.  [Abstract]

    Cytotoxicity assay on melanoma A375 WT cancer cell lines incubated with MC-Val-Cit-PAB-MMAF (ADC-MMAF) (0-1200 nM).

    MC-Val-Cit-PAB-MMAF purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jan 24;17(1):162.  [Abstract]

    MC-Val-Cit-PAB-MMAF (ADC-MMAF) (3.7 mg/kg; i.v.) was well tolerated in terms of weight changes of melanoma A375-bearing mice.

    View All Drug-Linker Conjugates for ADC Isoform Specific Products:

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    MC-Val-Cit-PAB-MMAF (Vc-MMAF) is a drug-linker conjugate for ADC by using the tubulin inhibitor, MMAF (HY-15579), linked via cathepsin cleavable MC-Val-Cit-PAB (HY-78738). MC-Val-Cit-PAB-MMAF shows antitumor activity[1].

    IC50 & Target[1]

    Auristatin

     

    In Vitro

    ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    MC-Val-Cit-PAB-MMAF Related Antibodies
    Molecular Weight

    1330.61

    Formula

    C68H103N11O16
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    OC([C@H](CC1=CC=CC=C1)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@@]([C@@H](C)CC)([H])N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN4C(C=CC4=O)=O)=O)=O)=O)C=C3)=O)=O)=O)=O)OC)=O)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, stored under nitrogen

    *The compound is unstable in solutions, freshly prepared is recommended.

    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (75.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.7515 mL 3.7577 mL 7.5153 mL
    5 mM 0.1503 mL 0.7515 mL 1.5031 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

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    (per animal)

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    (per animal)

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.25%

    SDS (392 KB)

    COA (247 KB) HNMR (389 KB) RP-HPLC (140 KB) LCMS (153 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 0.7515 mL 3.7577 mL 7.5154 mL 18.7884 mL
    5 mM 0.1503 mL 0.7515 mL 1.5031 mL 3.7577 mL
    10 mM 0.0752 mL 0.3758 mL 0.7515 mL 1.8788 mL
    15 mM 0.0501 mL 0.2505 mL 0.5010 mL 1.2526 mL
    20 mM 0.0376 mL 0.1879 mL 0.3758 mL 0.9394 mL
    25 mM 0.0301 mL 0.1503 mL 0.3006 mL 0.7515 mL
    30 mM 0.0251 mL 0.1253 mL 0.2505 mL 0.6263 mL
    40 mM 0.0188 mL 0.0939 mL 0.1879 mL 0.4697 mL
    50 mM 0.0150 mL 0.0752 mL 0.1503 mL 0.3758 mL
    60 mM 0.0125 mL 0.0626 mL 0.1253 mL 0.3131 mL
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    MC-Val-Cit-PAB-MMAF Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    MC-Val-Cit-PAB-MMAF863971-17-9Vc-MMAFDrug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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