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Cat. No.: HY-112786

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MC-Val-Cit-PAB-MMAF

(Synonyms: Vc-MMAF)

5 Cited Publications

Customer Review

Based on 5 publication(s) in Google Scholar

MC-Val-Cit-PAB-MMAF (Vc-MMAF) is a drug-linker conjugate for ADC by using the tubulin inhibitor, MMAF (HY-15579), linked via cathepsin cleavable MC-Val-Cit-PAB (HY-78738). MC-Val-Cit-PAB-MMAF shows antitumor activity.

For research use only. We do not sell to patients.

Purity: 99.25%
CAS No.: 863971-17-9
Formula: C₆₈H₁₀₃N₁₁O₁₆
Molecular Weight:1330.61

Storage:

4°C, stored under nitrogen

* The compound is unstable in solutions, freshly prepared is recommended.

MC-Val-Cit-PAB-MMAF Chemical Structure

CAS No.: 863971-17-9

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (5)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Auristatin

All Drug-Linker Conjugates for ADC Isoforms :

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 863971-17-9
Appearance Solid
Molecular Weight 1330.61
Formula C₆₈H₁₀₃N₁₁O₁₆
Color White to off-white
SMILES

OC([C@H](CC1=CC=CC=C1)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@@]([C@@H](C)CC)([H])N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN4C(C=CC4=O)=O)=O)=O)=O)C=C3)=O)=O)=O)=O)OC)=O)=O
Synonyms

Vc-MMAF
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

* The compound is unstable in solutions, freshly prepared is recommended.

Publications (5)

All Cell Proliferation/Viability AssayIn Vivo Efficacy Study

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Journal Impact Factor

Cell Death Dis

Preclinical profiling of antibody drug conjugates targeting oncofetal chondroitin sulfate. [Abstract]

2026 Jan 24;17(1):162. PMID: 41580438

MC-Val-Cit-PAB-MMAF purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jan 24;17(1):162. [Abstract]

MC-Val-Cit-PAB-MMAF (ADC-MMAF) (50 nM; 72 h) effectively killed A375 WT cells.

MC-Val-Cit-PAB-MMAF purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jan 24;17(1):162. [Abstract]

Cytotoxicity assay on melanoma A375 WT cancer cell lines incubated with MC-Val-Cit-PAB-MMAF (ADC-MMAF) (0-1200 nM).

MC-Val-Cit-PAB-MMAF purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jan 24;17(1):162. [Abstract]

MC-Val-Cit-PAB-MMAF (ADC-MMAF) (3.7 mg/kg; i.v.) was well tolerated in terms of weight changes of melanoma A375-bearing mice.
Int J Mol Sci

GD2-Targeted Minibody-Drug Conjugates Match the Potency of IgG-Based ADCs in a Mouse Cancer Model. [Abstract]

2026 Feb 19;27(4):1974. PMID: 41752109
Neoplasia

Rational payload selection enables high antitumoral efficacy of an anti-EGFR antibody-drug conjugate against ovarian tumors. [Abstract]

2026 Mar 12:74:101295. PMID: 41825107
Acta Biochim Biophys Sin (Shanghai)

A novel humanized MUC1 antibody-drug conjugate for the treatment of trastuzumab-resistant breast cancer. [Abstract]

2021 Dec 8;53(12):1625-1639. PMID: 34586349
J Pharm Sci

"Negative" Impact: The Role of Payload Charge in the Physicochemical Stability of Auristatin Antibody-Drug Conjugates. [Abstract]

2024 Aug;113(8):2433-2442. PMID: 38679233

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (75.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

0.7515 mL

3.7577 mL

7.5153 mL

5 mM

0.1503 mL

0.7515 mL

1.5031 mL

10 mM

0.0752 mL

0.3758 mL

0.7515 mL

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cheng X, et al. MORAb-202, an Antibody-Drug Conjugate Utilizing Humanized Anti-human FRα Farletuzumab and the Microtubule-targeting Agent Eribulin, has Potent Antitumor Activity. Mol Cancer Ther. 2018 Dec;17(12):2665-2675. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	0.7515 mL	3.7577 mL	7.5154 mL	18.7884 mL
	5 mM	0.1503 mL	0.7515 mL	1.5031 mL	3.7577 mL
	10 mM	0.0752 mL	0.3758 mL	0.7515 mL	1.8788 mL
	15 mM	0.0501 mL	0.2505 mL	0.5010 mL	1.2526 mL
	20 mM	0.0376 mL	0.1879 mL	0.3758 mL	0.9394 mL
	25 mM	0.0301 mL	0.1503 mL	0.3006 mL	0.7515 mL
	30 mM	0.0251 mL	0.1253 mL	0.2505 mL	0.6263 mL
	40 mM	0.0188 mL	0.0939 mL	0.1879 mL	0.4697 mL
	50 mM	0.0150 mL	0.0752 mL	0.1503 mL	0.3758 mL
	60 mM	0.0125 mL	0.0626 mL	0.1253 mL	0.3131 mL

Keywords

MC-Val-Cit-PAB-MMAF

5 Cited Publications

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (5)
Solvent & Solubility
- In Vitro
Purity & Documentation
References

1/16
1/16

MC-Val-Cit-PAB-MMAF purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jan 24;17(1):162. [Abstract]

Customer Validation
MC-Val-Cit-PAB-MMAF (ADC-MMAF) (50 nM; 72 h) effectively killed A375 WT cells.
1/16

MC-Val-Cit-PAB-MMAF purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jan 24;17(1):162. [Abstract]

Customer Validation
Cytotoxicity assay on melanoma A375 WT cancer cell lines incubated with MC-Val-Cit-PAB-MMAF (ADC-MMAF) (0-1200 nM).
1/16

MC-Val-Cit-PAB-MMAF purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jan 24;17(1):162. [Abstract]

Customer Validation
MC-Val-Cit-PAB-MMAF (ADC-MMAF) (3.7 mg/kg; i.v.) was well tolerated in terms of weight changes of melanoma A375-bearing mice.

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MC-Val-Cit-PAB-MMAF

Publications Citing Use of MedChemExpress (MCE) MC-Val-Cit-PAB-MMAF

All Drug-Linker Conjugates for ADC Isoforms

Biological Activity

Chemical Information

Publications (5)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

MC-Val-Cit-PAB-MMAF Related Classifications

HY-112786 Related Classifications