MC-Val-Cit-PAB-MMAF
Based on 5 publication(s) in Google Scholar
MC-Val-Cit-PAB-MMAF (Vc-MMAF) is a drug-linker conjugate for ADC by using the tubulin inhibitor, MMAF (HY-15579), linked via cathepsin cleavable MC-Val-Cit-PAB (HY-78738). MC-Val-Cit-PAB-MMAF shows antitumor activity.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.25%
- CAS No.: 863971-17-9
- 화학식: C68H103N11O16
- 분자량:1330.61
-
보관:
4°C, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
용액&용해도
- 순도&문서
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) MC-Val-Cit-PAB-MMAF
More
Customer Validation & Images
-
Cell Proliferation/Viability Assay
-
Cell Proliferation/Viability Assay
-
In Vivo Efficacy Study
All Drug-Linker Conjugates for ADC Isoforms
More
Biological Activity
|
Auristatin |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 863971-17-9
-
Appearance Solid
-
분자량 1330.61
-
화학식 C68H103N11O16
-
Color White to off-white
-
SMILES
OC([C@H](CC1=CC=CC=C1)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@@]([C@@H](C)CC)([H])N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN4C(C=CC4=O)=O)=O)=O)=O)C=C3)=O)=O)=O)=O)OC)=O)=O
-
Synonyms
Vc-MMAF
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
4°C, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
Publications (5)
-
Journal Impact Factor
-
Most Recent
-
Cell Death Dis
Preclinical profiling of antibody drug conjugates targeting oncofetal chondroitin sulfate. [Abstract]2026 Jan 24;17(1):162. PMID: 41580438
MC-Val-Cit-PAB-MMAF purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jan 24;17(1):162. [Abstract]
MC-Val-Cit-PAB-MMAF (ADC-MMAF) (50 nM; 72 h) effectively killed A375 WT cells.
MC-Val-Cit-PAB-MMAF purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jan 24;17(1):162. [Abstract]
Cytotoxicity assay on melanoma A375 WT cancer cell lines incubated with MC-Val-Cit-PAB-MMAF (ADC-MMAF) (0-1200 nM).
MC-Val-Cit-PAB-MMAF purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jan 24;17(1):162. [Abstract]
MC-Val-Cit-PAB-MMAF (ADC-MMAF) (3.7 mg/kg; i.v.) was well tolerated in terms of weight changes of melanoma A375-bearing mice.
-
Int J Mol Sci
GD2-Targeted Minibody-Drug Conjugates Match the Potency of IgG-Based ADCs in a Mouse Cancer Model. [Abstract]2026 Feb 19;27(4):1974. PMID: 41752109 -
Neoplasia
Rational payload selection enables high antitumoral efficacy of an anti-EGFR antibody-drug conjugate against ovarian tumors. [Abstract]2026 Mar 12:74:101295. PMID: 41825107 -
Acta Biochim Biophys Sin (Shanghai)
A novel humanized MUC1 antibody-drug conjugate for the treatment of trastuzumab-resistant breast cancer. [Abstract]2021 Dec 8;53(12):1625-1639. PMID: 34586349 -
J Pharm Sci
"Negative" Impact: The Role of Payload Charge in the Physicochemical Stability of Auristatin Antibody-Drug Conjugates. [Abstract]2024 Aug;113(8):2433-2442. PMID: 38679233
용액&용해도
DMSO : 100 mg/mL (75.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
-
Data Sheet (271 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.7515 mL | 3.7577 mL | 7.5154 mL | 18.7884 mL |
| 5 mM | 0.1503 mL | 0.7515 mL | 1.5031 mL | 3.7577 mL | |
| 10 mM | 0.0752 mL | 0.3758 mL | 0.7515 mL | 1.8788 mL | |
| 15 mM | 0.0501 mL | 0.2505 mL | 0.5010 mL | 1.2526 mL | |
| 20 mM | 0.0376 mL | 0.1879 mL | 0.3758 mL | 0.9394 mL | |
| 25 mM | 0.0301 mL | 0.1503 mL | 0.3006 mL | 0.7515 mL | |
| 30 mM | 0.0251 mL | 0.1253 mL | 0.2505 mL | 0.6263 mL | |
| 40 mM | 0.0188 mL | 0.0939 mL | 0.1879 mL | 0.4697 mL | |
| 50 mM | 0.0150 mL | 0.0752 mL | 0.1503 mL | 0.3758 mL | |
| 60 mM | 0.0125 mL | 0.0626 mL | 0.1253 mL | 0.3131 mL |
MC-Val-Cit-PAB-MMAF Related Classifications
HY-112786 Related Classifications
Powered by Bioz