1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. Gly3-VC-PAB-MMAE

Gly3-VC-PAB-MMAE 

Cat. No.: HY-131056
Handling Instructions

Gly3-VC-PAB-MMAE consists a cleavable ADC linker (Gly3-VC-PAB) and a potent tubulin inhibitor (MMAE). Gly3-VC-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Gly3-VC-PAB-MMAE Chemical Structure

Gly3-VC-PAB-MMAE Chemical Structure

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Description

Gly3-VC-PAB-MMAE consists a cleavable ADC linker (Gly3-VC-PAB) and a potent tubulin inhibitor (MMAE). Gly3-VC-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target

Auristatin

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

Molecular Weight

1294.58

Formula

C₆₄H₁₀₃N₁₃O₁₅

SMILES

CC[[email protected]@H]([[email protected]](N(C)C([[email protected]@H](NC([[email protected]@H](N(C)C(OCC1=CC=C(C=C1)NC([[email protected]@H](NC([[email protected]@H](NC(CNC(CNC(CN)=O)=O)=O)C(C)C)=O)CCCNC(N)=O)=O)=O)C(C)C)=O)C(C)C)=O)[[email protected]](OC)CC(N2[[email protected]]([[email protected]](OC)[[email protected]](C(N[[email protected]@H]([[email protected]](C3=CC=CC=C3)O)C)=O)C)CCC2)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Gly3-VC-PAB-MMAEDrug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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Product name:
Gly3-VC-PAB-MMAE
Cat. No.:
HY-131056
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