1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. DBCO-PEG4-VC-PAB-MMAE

DBCO-PEG4-VC-PAB-MMAE 

Cat. No.: HY-136314
Handling Instructions

DBCO-PEG4-VC-PAB-MMAE consists a ADC linker (DBCO-PEG4-VC-PAB) and a tubulin polymerization inhibitor MMAE (HY-15162). DBCO-PEG4-VC-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs). MMAE is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization.

For research use only. We do not sell to patients.

DBCO-PEG4-VC-PAB-MMAE Chemical Structure

DBCO-PEG4-VC-PAB-MMAE Chemical Structure

CAS No. : 2129164-91-4

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Description

DBCO-PEG4-VC-PAB-MMAE consists a ADC linker (DBCO-PEG4-VC-PAB) and a tubulin polymerization inhibitor MMAE (HY-15162). DBCO-PEG4-VC-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs). MMAE is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization[1].

IC50 & Target[1]

Duocarmycins

 

Molecular Weight

1658.03

Formula

C₈₈H₁₂₈N₁₂O₁₉

CAS No.

2129164-91-4

SMILES

CC[[email protected]](C)[[email protected]@H]([[email protected]@H](CC(N1[[email protected]@H](CCC1)[[email protected]@H]([[email protected]@H](C)C(N[[email protected]](C)[[email protected]@H](O)C2=CC=CC=C2)=O)OC)=O)OC)N(C([[email protected]](C(C)C)NC([[email protected]](C(C)C)N(C(OCC3=CC=C(NC([[email protected]](CCCNC(N)=O)NC([[email protected]](C(C)C)NC(CCOCCOCCOCCOCCNC(CCC(N4CC5=C(C=CC=C5)C#CC6=C4C=CC=C6)=O)=O)=O)=O)=O)C=C3)=O)C)=O)=O)C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DBCO-PEG4-VC-PAB-MMAEDrug-Linker Conjugates for ADCDrug-LinkerConjugateADCMMAEantibody-drugInhibitorinhibitorinhibit

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DBCO-PEG4-VC-PAB-MMAE
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HY-136314
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