1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. DBCO-(PEG2-VC-PAB-MMAE)2

DBCO-(PEG2-VC-PAB-MMAE)2 

Cat. No.: HY-126690
Handling Instructions

DBCO-(PEG2-VC-PAB-MMAE)2 is made by MMAE conjugated to the cleavable DBCO-(PEG2-VC-PAB)2 linker. Monomethyl auristatin E (MMAE), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.

For research use only. We do not sell to patients.

DBCO-(PEG2-VC-PAB-MMAE)2 Chemical Structure

DBCO-(PEG2-VC-PAB-MMAE)2 Chemical Structure

CAS No. : 2259318-55-1

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Description

DBCO-(PEG2-VC-PAB-MMAE)2 is made by MMAE conjugated to the cleavable DBCO-(PEG2-VC-PAB)2 linker. Monomethyl auristatin E (MMAE), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate[1].

IC50 & Target[1]

Auristatin

 

Molecular Weight

2835.50

Formula

C₁₄₉H₂₂₄N₂₂O₃₂

CAS No.

2259318-55-1

SMILES

O=C(N1[[email protected]](CCC1)([H])[[email protected]](OC)[[email protected]@H](C)C(N[[email protected]](C)[[email protected]](C2=CC=CC=C2)O)=O)C[[email protected]@H](OC)[[email protected]@]([[email protected]@H](C)CC)([H])N(C)C([[email protected]](C(C)C)NC([[email protected]](C(C)C)N(C)C(OCC(C=C3)=CC=C3NC([[email protected]](CCCNC(N)=O)NC([[email protected]](C(C)C)NC(CCOCCOCCN(CCOCCOCCC(N[[email protected]@H](C(C)C)C(N[[email protected]@H](CCCNC(N)=O)C(NC4=CC=C(COC(N(C)[[email protected]@H](C(C)C)C(N[[email protected]@H](C(C)C)C(N(C)[[email protected]]([[email protected]@H](C)CC)([H])[[email protected]](OC)CC(N5[[email protected]](CCC5)([H])[[email protected]](OC)[[email protected]@H](C)C(N[[email protected]](C)[[email protected]](C6=CC=CC=C6)O)=O)=O)=O)=O)=O)C=C4)=O)=O)=O)C(CCC(N7C8=CC=CC=C8C#CC9=CC=CC=C9C7)=O)=O)=O)=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DBCO-(PEG2-VC-PAB-MMAE)2Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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DBCO-(PEG2-VC-PAB-MMAE)2
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HY-126690
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