1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. DBCO-PEG4-MMAF

DBCO-PEG4-MMAF 

Cat. No.: HY-133492
Handling Instructions

DBCO-PEG4-MMAF is a drug-linker conjugate for ADC with potent antitumor activity by using the tubulin polymerization inhibitor, MMAF, linked via the cleavable linker DBCO-PEG4.

For research use only. We do not sell to patients.

DBCO-PEG4-MMAF Chemical Structure

DBCO-PEG4-MMAF Chemical Structure

CAS No. : 2360411-65-8

Size Price Stock Quantity
10 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

DBCO-PEG4-MMAF is a drug-linker conjugate for ADC with potent antitumor activity by using the tubulin polymerization inhibitor, MMAF, linked via the cleavable linker DBCO-PEG4.

IC50 & Target

Auristatin

 

Molecular Weight

1266.56

Formula

C₆₉H₉₉N₇O₁₅

CAS No.

2360411-65-8

SMILES

O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(NCCOCCOCCOCCOCCC(N(C)[[email protected]@H](C(C)C)C(N[[email protected]@H](C(C)C)C(N(C)[[email protected]]([[email protected]@H](C)CC)([H])[[email protected]](OC)CC(N(CCC4)[[email protected]]4([H])[[email protected]](OC)[[email protected]@H](C)C(N[[email protected]](C(O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (157.91 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7895 mL 3.9477 mL 7.8954 mL
5 mM 0.1579 mL 0.7895 mL 1.5791 mL
10 mM 0.0790 mL 0.3948 mL 0.7895 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 5 mg/mL (3.95 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 5 mg/mL (3.95 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (3.95 mM); Clear solution

*All of the co-solvents are provided by MCE.
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Keywords:

DBCO-PEG4-MMAFDrug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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Product Name:
DBCO-PEG4-MMAF
Cat. No.:
HY-133492
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