sulfo-SPDB-DM4
Based on 1 publication(s) in Google Scholar
sulfo-SPDB-DM4 is a agent-linker conjugate for ADC by using the maytansinebased payload (DM4, an antitubulin agent) via the sulfo-SPDB linker.
For research use only. We do not sell to patients.
- Purity: 99.81%
- CAS No.: 1626359-59-8
- Formula: C46H63ClN4O17S3
- Molecular Weight:1075.66
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Storage:
-80°C, protect from light, stored under nitrogen
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) sulfo-SPDB-DM4
MoreAll Drug-Linker Conjugates for ADC Isoforms
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Biological Activity
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Maytansinoids |
DM4, a structural analogue of maytansine, is a new thiol-containing and potent maytansinoid. DM4 is a cytotoxic maytansinoid drug. It is synthesized in order to link maytansinoids to antibodies via disulfide bonds. Maytansinoids inhibit tubulin polymerization and microtubule assembly and enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1626359-59-8
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Appearance Solid
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Molecular Weight 1075.66
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Formula C46H63ClN4O17S3
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Color White to yellow
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SMILES
C[C@]1([C@@](CC(N(C(C=C2C=C3OC)=C3Cl)C)=O)([H])OC([C@H](C)N(C)C(CCC(C)(C)SSCCC(S(=O)(O)=O)C(ON(C4=O)C(CC4)=O)=O)=O)=O)[C@H]([C@@H]([C@](OC5=O)([H])C[C@]([C@](/C=C/C=C(C)/C2)([H])OC)(N5)O)C)O1
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Shipping
Shipping with dry ice.
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Storage
-80°C, protect from light, stored under nitrogen
Publications (1)
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Journal Impact Factor
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Most Recent
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Clin Cancer Res
ZW191, an FRα-Targeted Topoisomerase 1 Inhibitor ADC with a Differentiated Antitumor Efficacy and Tolerability Profile. [Abstract]2026 Jul 1;32(13):2748-2764. PMID: 42007996
Solvent & Solubility
DMSO : 50 mg/mL (46.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9297 mL | 4.6483 mL | 9.2966 mL | 23.2415 mL |
| 5 mM | 0.1859 mL | 0.9297 mL | 1.8593 mL | 4.6483 mL | |
| 10 mM | 0.0930 mL | 0.4648 mL | 0.9297 mL | 2.3242 mL | |
| 15 mM | 0.0620 mL | 0.3099 mL | 0.6198 mL | 1.5494 mL | |
| 20 mM | 0.0465 mL | 0.2324 mL | 0.4648 mL | 1.1621 mL | |
| 25 mM | 0.0372 mL | 0.1859 mL | 0.3719 mL | 0.9297 mL | |
| 30 mM | 0.0310 mL | 0.1549 mL | 0.3099 mL | 0.7747 mL | |
| 40 mM | 0.0232 mL | 0.1162 mL | 0.2324 mL | 0.5810 mL |
sulfo-SPDB-DM4 Related Classifications
HY-101141 Related Classifications
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