1. Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  2. Androgen Receptor Cytochrome P450
  3. N-Desmethyl-Apalutamide

N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration.

For research use only. We do not sell to patients.

N-Desmethyl-Apalutamide Chemical Structure

N-Desmethyl-Apalutamide Chemical Structure

CAS No. : 1332391-11-3

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 495 In-stock
Solution
10 mM * 1 mL in DMSO USD 495 In-stock
Solid
1 mg USD 200 In-stock
5 mg USD 450 In-stock
10 mg USD 680 In-stock
25 mg USD 1200 In-stock
50 mg USD 1700 In-stock
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration[1][2][3].

IC50 & Target

CYP3A4 and CYP2B6[1]; Androgen receptor[2]

Molecular Weight

463.41

Formula

C20H13F4N5O2S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N)C1=CC=C(N(C(N(C2=CC(C(F)(F)F)=C(C#N)N=C2)C3=O)=S)C43CCC4)C=C1F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (215.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1579 mL 10.7896 mL 21.5792 mL
5 mM 0.4316 mL 2.1579 mL 4.3158 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.68%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1579 mL 10.7896 mL 21.5792 mL 53.9479 mL
5 mM 0.4316 mL 2.1579 mL 4.3158 mL 10.7896 mL
10 mM 0.2158 mL 1.0790 mL 2.1579 mL 5.3948 mL
15 mM 0.1439 mL 0.7193 mL 1.4386 mL 3.5965 mL
20 mM 0.1079 mL 0.5395 mL 1.0790 mL 2.6974 mL
25 mM 0.0863 mL 0.4316 mL 0.8632 mL 2.1579 mL
30 mM 0.0719 mL 0.3597 mL 0.7193 mL 1.7983 mL
40 mM 0.0539 mL 0.2697 mL 0.5395 mL 1.3487 mL
50 mM 0.0432 mL 0.2158 mL 0.4316 mL 1.0790 mL
60 mM 0.0360 mL 0.1798 mL 0.3597 mL 0.8991 mL
80 mM 0.0270 mL 0.1349 mL 0.2697 mL 0.6743 mL
100 mM 0.0216 mL 0.1079 mL 0.2158 mL 0.5395 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
N-Desmethyl-Apalutamide
Cat. No.:
HY-135331
Quantity:
MCE Japan Authorized Agent: