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    Metabolic Enzyme/Protease
  2. Androgen Receptor
    Cytochrome P450
  3. N-Desmethyl-Apalutamide

N-Desmethyl-Apalutamide 

Cat. No.: HY-135331 Purity: 97.24%
Handling Instructions

N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration.

For research use only. We do not sell to patients.

N-Desmethyl-Apalutamide Chemical Structure

N-Desmethyl-Apalutamide Chemical Structure

CAS No. : 1332391-11-3

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1 mg USD 250 In-stock
Estimated Time of Arrival: December 31
5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
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Description

N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration[1][2][3].

IC50 & Target

CYP3A4 and CYP2B6[1]; Androgen receptor[2]

Molecular Weight

463.41

Formula

C₂₀H₁₃F₄N₅O₂S

CAS No.

1332391-11-3

SMILES

O=C(N)C1=CC=C(N(C(N(C2=CC(C(F)(F)F)=C(C#N)N=C2)C3=O)=S)C43CCC4)C=C1F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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Keywords:

N-Desmethyl-ApalutamideAndrogen ReceptorCytochrome P450CYPsMetabolitepharmacologicalCYP2C8CYP3A4CYP2B6plasma-proteinsInhibitorinhibitorinhibit

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N-Desmethyl-Apalutamide
Cat. No.:
HY-135331
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