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    Metabolic Enzyme/Protease
  2. Androgen Receptor
    Cytochrome P450
  3. N-Desmethyl Apalutamide

N-Desmethyl Apalutamide 

Cat. No.: HY-135331
Handling Instructions

N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration.

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N-Desmethyl Apalutamide Chemical Structure

N-Desmethyl Apalutamide Chemical Structure

CAS No. : 1332391-11-3

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Description

N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration[1][2][3].

IC50 & Target

CYP3A4 and CYP2B6[1]; Androgen receptor[2]

Molecular Weight

463.41

Formula

C₂₀H₁₃F₄N₅O₂S

CAS No.

1332391-11-3

SMILES

O=C(N)C1=CC=C(N(C(N(C2=CC(C(F)(F)F)=C(C#N)N=C2)C3=O)=S)C43CCC4)C=C1F

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

N-Desmethyl ApalutamideAndrogen ReceptorCytochrome P450CYPsMetabolitepharmacologicalCYP2C8CYP3A4CYP2B6plasma-proteinsInhibitorinhibitorinhibit

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N-Desmethyl Apalutamide
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HY-135331
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