2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis
  3. Nucleoside Antimetabolite/Analog Drug Metabolite Apoptosis DNA/RNA Synthesis
  4. CNDAC hydrochloride

CNDAC hydrochloride is a metabolite of the orally active agent Sapacitabine (HY-16445), and a nucleoside analog. CNDAC hydrochloride induces DNA damage and apoptosis.

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CNDAC hydrochloride Chemical Structure

CNDAC hydrochloride Chemical Structure

CAS No. : 134665-72-8

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Solid + Solvent
10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Other Forms of CNDAC hydrochloride:

CNDAC hydrochloride Related Antibodies

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Description

CNDAC hydrochloride is a metabolite of the orally active agent Sapacitabine (HY-16445), and a nucleoside analog. CNDAC hydrochloride induces DNA damage and apoptosis[1][2].

In Vitro

CNDAC has a unique mechanism of action: after incorporation into DNA, it induces single-strand breaks (SSBs) that are converted into double-strand breaks (DSBs) when cells go through a second S phase[1].
Lack of Rad51D and XRCC3 sensitizes cells to CNDAC (0-1 μM; 24 h)[1].
CNDAC (0-100 μM; 3 days) inhibits proliferation of HL-60 and THP-1 cells[2].
CNDAC (0-10 μM; 3-6 days) induces apoptosis in HL-60 and THP-1 cells[2].
CNDAC (6 μM; 48 h) induces cell cycle arrest in the G2 phase following a delayed S phase in HCT116 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CNDAC hydrochloride Related Antibodies

Cell Viability Assay[1]

Cell Line: Rad51D-deficient 51D1, Rad51D-complemented 51D1.3, wild-type AA8 and XRCC3-deficient irs1SF CHO cells
Concentration: 0-1 μM
Incubation Time: 24 h
Result: Inhibited cell survival with IC50s of 0.006, 0.32, 0.48 and 0.0053 μM against Rad51D-deficient 51D1, Rad51D-complemented 51D1.3, wild-type AA8 and XRCC3-deficient irs1SF cell lines, respectively.

Cell Proliferation Assay[2]

Cell Line: HL-60 and THP-1 cells
Concentration: 0-100 μM
Incubation Time: 3 days
Result: Inhibited proliferation with IC50s of 1.5832 μM and 0.84 μM against HL-60 and THP-1 cells, respectively.

Apoptosis Analysis[2]

Cell Line: HL-60 and THP-1 cells
Concentration: 0, 0.5, 1, 2, 3, 4, 5 and 10 μM
Incubation Time: 3, 4, 5, and 6 days
Result: Induced apoptosis in both cells.

Cell Cycle Analysis[3]

Cell Line: HCT116
Concentration: 6 μM
Incubation Time: 48 h
Result: 36 and 36% of cells were arrested in late-S and G2/M phases, respectively.
In Vivo

CNDAC (20mg/kg; i.p.; daily for 10 days) shows antitumor activity in mice[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CDF1 mice, P388 tumor model[4]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection, daily for 10 days
Result: Greatly increased the survival time and survival rate.
Molecular Weight

288.69

Formula

C10H13ClN4O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N=C(N)C=C1)N1[C@H]2[C@@H](C#N)[C@H](O)[C@@H](CO)O2.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (432.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4639 mL 17.3196 mL 34.6392 mL
5 mM 0.6928 mL 3.4639 mL 6.9278 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4639 mL 17.3196 mL 34.6392 mL 86.5981 mL
5 mM 0.6928 mL 3.4639 mL 6.9278 mL 17.3196 mL
10 mM 0.3464 mL 1.7320 mL 3.4639 mL 8.6598 mL
15 mM 0.2309 mL 1.1546 mL 2.3093 mL 5.7732 mL
20 mM 0.1732 mL 0.8660 mL 1.7320 mL 4.3299 mL
25 mM 0.1386 mL 0.6928 mL 1.3856 mL 3.4639 mL
30 mM 0.1155 mL 0.5773 mL 1.1546 mL 2.8866 mL
40 mM 0.0866 mL 0.4330 mL 0.8660 mL 2.1650 mL
50 mM 0.0693 mL 0.3464 mL 0.6928 mL 1.7320 mL
60 mM 0.0577 mL 0.2887 mL 0.5773 mL 1.4433 mL
80 mM 0.0433 mL 0.2165 mL 0.4330 mL 1.0825 mL
100 mM 0.0346 mL 0.1732 mL 0.3464 mL 0.8660 mL
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CNDAC hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CNDAC134665-72-8Nucleoside Antimetabolite/AnalogDrug MetaboliteApoptosisDNA/RNA Synthesisacute myelogenous leukemiaAMLCHOHL-60THP-1Inhibitorinhibitorinhibit

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