1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. (rel)-Asperparaline A

(rel)-Asperparaline A (Synonyms: (rel)-Aspergillimide; (rel)-VM55598)

Cat. No.: HY-124874
Handling Instructions

(rel)-Asperparaline A ((rel)-Aspergillimide), an anthelmintic metabolite, is isolated from okara that has been fermented with Aspergillus japonicas JV-23. (rel)-Asperparaline A is also a potent and selective antagonist of nAChR. (rel)-Asperparaline A exhibits paralytic activity in silk worms.

For research use only. We do not sell to patients.

(rel)-Asperparaline A Chemical Structure

(rel)-Asperparaline A Chemical Structure

CAS No. : 195966-93-9

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Description

(rel)-Asperparaline A ((rel)-Aspergillimide), an anthelmintic metabolite, is isolated from okara that has been fermented with Aspergillus japonicas JV-23. (rel)-Asperparaline A is also a potent and selective antagonist of nAChR. (rel)-Asperparaline A exhibits paralytic activity in silk worms[1][2].

In Vitro

Asperparaline A (1 μM; 1 min) markedly and reversibly blocks the acetylcholine (Ach; 10 µM)-induced current in the silkworm larval neurons[2].
Asperparaline A (1-1000 nM; 1 min) differentially blocks the peak and slowly desensitizing currents, with IC50s of 20.2 and 39.6 nM, respectively[2].
Asperparaline A (10 μM; 1 min) reduces the peak current amplitude of the ACh (100 µM)-induced response of α3β4 nAChR by 33.4%, while barely influencing the amplitudes of the responses to ACh of the α4β2 and α7 nAChRs in X. laevis oocytes[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Asperparaline A (10 μg/g; p.o.) exhibits paralysis against silk worms within 1 h and lasts for 7 to 10 h[1].
Asperparaline A (3 μg/g; injection with a micro-syringe) exhibits paralysis activity against silk worms within 20 min and lasts for 4 to 5 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

359.46

Formula

C₂₀H₂₉N₃O₃

CAS No.
SMILES

CN(C1=O)C(C[[email protected]@]2(CC3=O)C(N3C)=O)(CN(CC[[email protected]@H]4C)C14C5)[[email protected]]5([H])C2(C)C.[Rotation (-)]

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

(rel)-Asperparaline A(rel)-Aspergillimide (rel)-VM55598nAChRNicotinic acetylcholine receptorsanthelminticokaraAspergillusjaponicasparalyticInhibitorinhibitorinhibit

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(rel)-Asperparaline A
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