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Results for "

paralytic

" in MedChemExpress (MCE) Product Catalog:

5

Inhibitors & Agonists

4

Peptides

2

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P5149
    αC-Conotoxin PrXA

    αC-PrXA

    		 nAChR Neurological Disease
    αC-Conotoxin PrXA is a paralytic peptide neurotoxin and a competitive nAChR antagonist, with IC50s of 1.8 nM (α1β1εδ, adult) and 3.0 nM (α1β1γδ, fetal), respectively. αC-Conotoxin PrXA competes with α-bungarotoxin at the α/δ and α/γ subunit interfaces of the nAChR, shows high specificity against neuromuscular nAChR .
    αC-Conotoxin PrXA
  • HY-124874
    (rel)-Asperparaline A

    (rel)-Aspergillimide; (rel)-VM55598

    		 nAChR Neurological Disease
    (rel)-Asperparaline A ((rel)-Aspergillimide), an anthelmintic metabolite, is isolated from okara that has been fermented with Aspergillus japonicas JV-23. (rel)-Asperparaline A is also a potent and selective antagonist of nAChR. (rel)-Asperparaline A exhibits paralytic activity in silk worms .
    (rel)-Asperparaline A
  • HY-P5148
    α-Conotoxin BuIA

    		nAChR Neurological Disease
    α-Conotoxin BuIA is a paralytic peptide neurotoxin and a competitive nAChR antagonist, with IC50s of 0.258 nM (α6/α3β2), 1.54 nM (α6/α3β4), 5.72 nM (α3β2), respectively. α-Conotoxin BuIA can be used to distinguish nAChRs containing β2- and β4-subunit, respectively. α-Conotoxin BuIA distinguishes among αxβ2 nAChRs with a rank order potency of α6>α3>α2>α4 .
    α-Conotoxin BuIA
  • HY-P5147
    α-Conotoxin GID

    		nAChR Neurological Disease
    α-Conotoxin GID is a paralytic peptide neurotoxin and a selective antagonist of nAChR, with IC50s of 5 nM (α7), 3 nM (α3β2)， 150 nM (α4β2), respectively. α-Conotoxin GID is small disulfide-rich peptide, with potential to inhibit chronic pain. α-Conotoxin GID contains a C-terminal carboxylate, thus substitution with a C-terminal carboxamide results in loss of α4β2 nAChR. α-Conotoxin GID can be isolated from the Conus species .
    α-Conotoxin GID
  • HY-N12100
    Gonyautoxin I

    GTX1

    		 Others Neurological Disease
    Gonyautoxin I (GTX1) is a neurotoxin that can be isolated from Paralytic shellfish .
    Gonyautoxin I

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