4-Quinolinecarboxylic acid
Based on 1 Customer Validation
4-Quinolinecarboxylic acid (Cinchoninic acid; 4-Carboxyquinoline; NSC 13138) is a quinoline derivative and also an Endogenous Metabolite. 4-Quinolinecarboxylic acid can serve as the sole carbon source for the growth of the soil bacterium Microbacterium sp. H2.
For research use only. We do not sell to patients.
- Purity: 99.58%
- CAS No.: 486-74-8
- Formula: C10H7NO2
- Molecular Weight:173.17
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>50 μM
Compound: QLin
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Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 37956506] |
| HCT-116 | IC50 |
>50 μM
Compound: QLin
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Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 37956506] |
| MCF-10A | IC50 |
>50 μM
Compound: QLin
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Cytotoxicity against human MCF-10A cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Cytotoxicity against human MCF-10A cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
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[PMID: 37956506] |
| MCF7 | IC50 |
>50 μM
Compound: QLin
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 37956506] |
| NCI/ADR-RES | IC50 |
>50 μM
Compound: QLin
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Antiproliferative activity against human MCF7ADR cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human MCF7ADR cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
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[PMID: 37956506] |
4-Quinolinecarboxylic acid serves as the sole carbon source to support the growth of *Microbacterium* sp. H2. When the mutant strain M17 is co-cultured with this substrate and Succinic acid (HY-N0420), it sequentially produces two metabolites, namely 2-oxo-1,2-dihydroquinoline-4-carboxylic acid and 8-hydroxy-2-oxo-2H-1-benzopyran-4-carboxylic acid, both of which can independently act as carbon sources for the wild-type strain. Substrate degradation initiates with the oxidation at the C2 position of the pyridine ring[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 486-74-8
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Appearance Solid
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Molecular Weight 173.17
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Formula C10H7NO2
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Color Light brown to brown
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SMILES
O=C(C1=CC=NC2=CC=CC=C12)O
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Synonyms
Cinchoninic acid; 4-Carboxyquinoline; NSC 13138
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (288.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (14.44 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (14.44 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (278 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.7747 mL | 28.8734 mL | 57.7467 mL | 144.3668 mL |
| 5 mM | 1.1549 mL | 5.7747 mL | 11.5493 mL | 28.8734 mL | |
| 10 mM | 0.5775 mL | 2.8873 mL | 5.7747 mL | 14.4367 mL | |
| 15 mM | 0.3850 mL | 1.9249 mL | 3.8498 mL | 9.6245 mL | |
| 20 mM | 0.2887 mL | 1.4437 mL | 2.8873 mL | 7.2183 mL | |
| 25 mM | 0.2310 mL | 1.1549 mL | 2.3099 mL | 5.7747 mL | |
| 30 mM | 0.1925 mL | 0.9624 mL | 1.9249 mL | 4.8122 mL | |
| 40 mM | 0.1444 mL | 0.7218 mL | 1.4437 mL | 3.6092 mL | |
| 50 mM | 0.1155 mL | 0.5775 mL | 1.1549 mL | 2.8873 mL | |
| 60 mM | 0.0962 mL | 0.4812 mL | 0.9624 mL | 2.4061 mL | |
| 80 mM | 0.0722 mL | 0.3609 mL | 0.7218 mL | 1.8046 mL | |
| 100 mM | 0.0577 mL | 0.2887 mL | 0.5775 mL | 1.4437 mL |
4-Quinolinecarboxylic acid Related Classifications
HY-Y0057 Related Classifications
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