1. Protein Tyrosine Kinase/RTK
    Metabolic Enzyme/Protease
  2. FLT3
    Drug Metabolite
  3. (R)-3-Hydroxy Midostaurin

(R)-3-Hydroxy Midostaurin (Synonyms: (R)-CGP52421)

Cat. No.: HY-108263B
Handling Instructions

(R)-3-Hydroxy Midostaurin ((R)-CGP52421) is a potent kinases inhibitor. (R)-3-Hydroxy Midostaurin is a major metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (R)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML).

For research use only. We do not sell to patients.

(R)-3-Hydroxy Midostaurin Chemical Structure

(R)-3-Hydroxy Midostaurin Chemical Structure

CAS No. : 155848-20-7

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

(R)-3-Hydroxy Midostaurin ((R)-CGP52421) is a potent kinases inhibitor. (R)-3-Hydroxy Midostaurin is a major metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (R)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML)[1].

In Vitro

(R)-3-Hydroxy Midostaurin ((R)-CGP52421; compound 5) has IC50 values in the range of 200-400 nM against the ITD and D835Y mutants and low micromolar activity against the wild-type enzyme[1].
The epimeric mixture of metabolites ((R)-3-Hydroxy Midostaurin + (S)-3-Hydroxy Midostaurin) substantially inhibits the proliferation of only the Tel-PDGFRβ (GI50=63 nM), KIT D816V (GI50=320 nM), and FLT3-ITD (GI50=650 nM) BaF3 cell lines, while the wild-type cells are relatively insensitive[1].

Molecular Weight

586.64

Formula

C₃₅H₃₀N₄O₅

CAS No.

155848-20-7

SMILES

O[[email protected]]1NC(C2=C1C(C3=C4C=CC=C3)=C5N4[[email protected]]6(O[[email protected]@H](N7C5=C2C8=C7C=CC=C8)C[[email protected]]([[email protected]]6OC)N(C(C9=CC=CC=C9)=O)C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

(R)-3-Hydroxy Midostaurin(R)-CGP52421FLT3Drug MetaboliteCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3VEGFR-2LTKPDPK1metabolitemidostaurinPKC412hepaticCYP3A4enzymeacutemyeloidleukemiaAMLInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
(R)-3-Hydroxy Midostaurin
Cat. No.:
HY-108263B
Quantity:
MCE Japan Authorized Agent: