155848-20-7
Chemical Structure
(R)-3-Hydroxy Midostaurin
Synonym(s): (R)-CGP52421
- CAS No.: 155848-20-7
- Formula:C35H30N4O5
- Molecular Weight:586.64
IUPAC Name: N-((5R,7R,8R,9S,14R)-14-hydroxy-8-methoxy-9-methyl-16-oxo-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-7-yl)-N-methylbenzamide
InChIKey: ZZSBPGIGIUFJRA-ZFQVYDAQSA-N
SMILES: O[C@H]1NC(C2=C1C(C3=C4C=CC=C3)=C5N4[C@]6(O[C@@H](N7C5=C2C8=C7C=CC=C8)C[C@H]([C@H]6OC)N(C(C9=CC=CC=C9)=O)C)C)=O
Biological Activity: (R)-3-Hydroxy Midostaurin ((R)-CGP52421) is a potent kinases inhibitor. (R)-3-Hydroxy Midostaurin is a major metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (R)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML)[1].
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(R)-3-Hydroxy Midostaurin | (R)-3-Hydroxy Midostaurin ((R)-CGP52421) is a potent kinases inhibitor. (R)-3-Hydroxy Midostaurin is a major metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (R)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML). | |||||||||||||||||||||
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