2. Protein Tyrosine Kinase/RTK
  3. FLT3
  4. 3-Hydroxy Midostaurin

3-Hydroxy Midostaurin  (Synonyms: CGP52421)

Cat. No.: HY-108263 Purity: 97.02%
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3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412.

For research use only. We do not sell to patients.

3-Hydroxy Midostaurin Chemical Structure

3-Hydroxy Midostaurin Chemical Structure

CAS No. : 179237-49-1

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Based on 1 publication(s) in Google Scholar

Other Forms of 3-Hydroxy Midostaurin:

3-Hydroxy Midostaurin Related Antibodies

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Description

3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412[1].

IC50 & Target

IC50: 132 nM (FLT3 in culture medium) and 9.8 μM (FLT3 in plasma)[1]
In Vitro

CGP52421 (200, 400, 600, 800, 1000 nM) is more cytotoxic than PKC412 over the dose range 100 to 500 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

3-Hydroxy Midostaurin Related Antibodies
Molecular Weight

586.64

Formula

C35H30N4O5
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

OC1NC(C2=C1C(C3=C4C=CC=C3)=C5N4[C@]6(O[C@@H](N7C5=C2C8=C7C=CC=C8)C[C@H]([C@H]6OC)N(C(C9=CC=CC=C9)=O)C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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3-Hydroxy Midostaurin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-Hydroxy Midostaurin179237-49-1CGP52421CGP 52421CGP-52421FLT3Cluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Inhibitorinhibitorinhibit

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