1. Protein Tyrosine Kinase/RTK
  2. FLT3
  3. 3-Hydroxy Midostaurin

3-Hydroxy Midostaurin (Synonyms: CGP52421)

Cat. No.: HY-108263
Handling Instructions

3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412.

For research use only. We do not sell to patients.

3-Hydroxy Midostaurin Chemical Structure

3-Hydroxy Midostaurin Chemical Structure

CAS No. : 179237-49-1

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Description

3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412[1].

IC50 & Target

IC50: 132 nM (FLT3 in culture medium) and 9.8 μM (FLT3 in plasma)[1]

In Vitro

CGP52421 (200, 400, 600, 800, 1000 nM) is more cytotoxic than PKC412 over the dose range 100 to 500 nM[1].

Molecular Weight

586.64

Formula

C₃₅H₃₀N₄O₅

CAS No.

179237-49-1

SMILES

O[[email protected]]1NC(C2=C1C(C3=C4C=CC=C3)=C5N4[[email protected]]6(O[[email protected]@H](N7C5=C2C8=C7C=CC=C8)C[[email protected]]([[email protected]]6OC)N(C(C9=CC=CC=C9)=O)C)C)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

3-Hydroxy MidostaurinCGP52421CGP 52421CGP-52421FLT3Cluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Inhibitorinhibitorinhibit

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3-Hydroxy Midostaurin
Cat. No.:
HY-108263
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