2. PROTAC
  3. Ligands for E3 Ligase
  4. CC-17369

CC-17369  (Synonyms: 7-Hydroxy pomalidomide; Pomalidomide metabolite M16)

Cat. No.: HY-123215 Purity: 98.13%
COA Handling Instructions

CC-17369 (7-Hydroxy pomalidomide) is a metabolite of Pomalidomide. CC-17369 is the Pomalidomide -based cereblon (CRBN) ligand used in the recruitment of CRBN protein. CC-17369 can be connected to the ligand for protein by a linker to form PROTAC.

For research use only. We do not sell to patients.

CC-17369 Chemical Structure

CC-17369 Chemical Structure

CAS No. : 1547162-46-8

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 220 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 220 In-stock
Solid
5 mg USD 200 In-stock
10 mg USD 350 In-stock
25 mg USD 700 In-stock
50 mg USD 1100 In-stock
100 mg USD 1650 In-stock
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500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP

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Description

CC-17369 (7-Hydroxy pomalidomide) is a metabolite of Pomalidomide. CC-17369 is the Pomalidomide -based cereblon (CRBN) ligand used in the recruitment of CRBN protein. CC-17369 can be connected to the ligand for protein by a linker to form PROTAC[1].

IC50 & Target[2]

Cereblon

 

Molecular Weight

289.24

Appearance

Solid

Formula

C13H11N3O5
CAS No.
SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C(O)=CC=C3N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (172.87 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4573 mL 17.2867 mL 34.5734 mL
5 mM 0.6915 mL 3.4573 mL 6.9147 mL
10 mM 0.3457 mL 1.7287 mL 3.4573 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (8.64 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (8.64 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

CC-173691547162-46-87-Hydroxy pomalidomide Pomalidomide metabolite M16CC17369CC 17369Pomalidomide metabolite M16Pomalidomide metabolite M 16Pomalidomide metabolite M-16Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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