Isopropyl unoprostone
Based on 1 Customer Validation
Isopropyl unoprostone (Unoprostone isopropyl ester), an analogue of a prostaglandin metabolite, is a potent large conductance Ca2+-activated K+ (BK) channels activator. Isopropyl unoprostone has antiglaucoma effects, lowering intraocular pressure (IOP) by increasing aqueous humour outflow. Isopropyl unoprostone can improve retinal sensitivity and the protection of central retinal sensitivity.
For research use only. We do not sell to patients.
- Purity: 95.1%
- CAS No.: 120373-24-2
- Formula: C25H44O5
- Molecular Weight:424.61
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Storage:
Solution, -20°C, 2 years
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
BK channels[1]
Isopropyl unoprostone (0.01-1 μM; 24 h) protects against H2O2-induced 661W cell death[2].
Isopropyl unoprostone (0.1-3 μM; 24 h) reduced the morphological change of 661W cells and protects against light-induced cell death[2].
Isopropyl unoprostone (0.001-1 μM; 48 h) suppresses light-induced phagocytotic dysfunction in ARPE-19 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:661W (treated with Isopropyl unoprostone for 1 h, then added H2O2)
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Concentration:0.01, 0.1 and 1 μM
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Incubation Time:24 h
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Result:Protected against H2O2-induced cell death in a concentration-dependent manner.
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Cell Line:661W (treated with Isopropyl unoprostone for 1 h, then exposed to 2,500 lux of white fluorescent light)
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Concentration:0.1, 1 and 3 μM
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Incubation Time:24 h
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Result:Protected against light-induced cell death in a concentration-dependent manner, and the effect was significant at the 1 and 3 μM concentrations; reduced the morphological change (the transition to a rounder shape) which is potentially indicative of a pre-apoptotic stage.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 120373-24-2
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Appearance Liquid
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Molecular Weight 424.61
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Formula C25H44O5
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Color Colorless to light yellow
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SMILES
O=C(OC(C)C)CCC/C=C\C[C@@H]1[C@@H](CCC(CCCCCCC)=O)[C@H](O)C[C@@H]1O
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Synonyms
Unoprostone isopropyl ester; UF-021
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Purity & Documentation
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Data Sheet (272 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Haria M, et al. Unoprostone (isopropyl unoprostone). Drugs Aging. 1996 Sep;9(3):213-8; discussion 219-20. [Content Brief]
[2]. Tsuruma K, et al. Unoprostone reduces oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction, by activating BK channels. Mol Vis. 2011;17:3556-65. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Isopropyl unoprostone Related Classifications
HY-109545 Related Classifications
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