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  3. PF 1022A

PF 1022A 

Cat. No.: HY-12361 Purity: 99.12%
Handling Instructions

PF 1022A is a cyclooctadepsipeptide with broadspectrum anthelmintic properties produced by fermentation of the fungus Mycelia sterilia. PF 1022A is a channel-forming ionophore. PF 1022A showes strong anthelmintic activities against Ascaridia galli in chickens. PF 1022A also can be used for angiostrongyliasis research.

For research use only. We do not sell to patients.

PF 1022A Chemical Structure

PF 1022A Chemical Structure

CAS No. : 133413-70-4

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 626 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 626 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE PF 1022A

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PF 1022A is a cyclooctadepsipeptide with broadspectrum anthelmintic properties produced by fermentation of the fungus Mycelia sterilia. PF 1022A is a channel-forming ionophore. PF 1022A showes strong anthelmintic activities against Ascaridia galli in chickens. PF 1022A also can be used for angiostrongyliasis research[1][2][3].

In Vitro

PF 1022A binds to the latrophilin-like transmembrane receptor important for pharyngeal pumping in nematodes. Furthermore, PF 1022A binds to GABA receptors, which might contribute to the anthelmintic effect[1].
In vitro, PF 1022A shows low activity on embryonation but significantly inhibits egg hatch (10 and 100 μg/mL), whereas albendazole (10 and 100 μg/mL) reveales statistically significant inhibitions of both embryonation and egg hatch. PF 1022A (1-100 μg/mL) completely inhibits larval movement at most examination points[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

949.18

Formula

C52H76N4O12

CAS No.
SMILES

O=C(N([[email protected]](C(O[[email protected]](C(N([[email protected]](C(O[[email protected]](CC1=CC=CC=C1)C2=O)=O)CC(C)C)C)=O)([H])C)=O)CC(C)C)C)[[email protected]](OC([[email protected]@H](N(C([[email protected]](OC([[email protected]](N2C)([H])CC(C)C)=O)C)=O)C)CC(C)C)=O)CC3=CC=CC=C3

Structure Classification
Source

Mycelia Sterilia PF1022

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 43 mg/mL (45.30 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0535 mL 5.2677 mL 10.5354 mL
5 mM 0.2107 mL 1.0535 mL 2.1071 mL
10 mM 0.1054 mL 0.5268 mL 1.0535 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.63 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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PF 1022A
Cat. No.:
HY-12361
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