A new anthelmintic cyclodepsipeptide, PF1022A

  • J Antibiot (Tokyo). 1992 May;45(5):692-7. doi: 10.7164/antibiotics.45.692.
T Sasaki  1 ,  M Takagi ,  T Yaguchi ,  S Miyadoh ,  T Okada ,  M Koyama
Affiliations
  • 1. Pharmaceutical Research Laboratories, Meiji Seika Kaisha Ltd., Yokohama, Japan.
PMID: 1624372 DOI: 10.7164/antibiotics.45.692
Abstract

The novel anthelmintic cyclodepsipeptide PF1022A was isolated from cultured mycelia of Mycelia Sterilia PF1022 (FERM BP-2671). It showed strong anthelmintic activities against Ascaridia galli in chickens. The structure of PF1022A was determined to be cyclo(D-lactyl-L-N-methylleucyl-D-3-phenyllactyl-L-N-meth ylleucyl-D-lactyl-L-N- methylleucyl-D-3-phenyllactyl-L-N-methylleucyl) by spectroscopic analyses and chemical studies.

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