Etiocholanolone-d5
Based on 1 Customer Validation
Etiocholanolone-d5 is the deuterium labeled Etiocholanolone. Etiocholanolone (5β-Androsterone) is the excreted metabolite of testosterone and has anticonvulsant activity. Etiocholanolone is a less potent?neurosteroid positive allosteric modulator?(PAM) of the GABAA?receptor than its?enantiomer form.
For research use only. We do not sell to patients.
- Purity: 99.20%
- CAS No.: 1620102-33-1
- Formula: C19H25D5O2
- Molecular Weight:295.47
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1620102-33-1
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Unlabeled Cas 53-42-9
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Appearance Solid
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Molecular Weight 295.47
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Formula C19H25D5O2
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Color White to off-white
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SMILES
C[C@@]12[C@]3([H])[C@](CC[C@]1([H])C([2H])([2H])[C@](C([2H])([2H])C2)([2H])O)([H])[C@@]4([H])[C@](CC3)(C(CC4)=O)C
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Synonyms
5β-Androsterone-d5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (169.22 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Ping Li,et al. Natural and Enantiomeric Etiocholanolone Interact With Distinct Sites on the Rat alpha1beta2gamma2L GABAA Receptor. Mol Pharmacol. 2007 Jun;71(6):1582-90. [Content Brief]
[3]. Dorota Zolkowska, et al. Anticonvulsant Potencies of the Enantiomers of the Neurosteroids Androsterone and Etiocholanolone Exceed Those of the Natural Forms. Psychopharmacology (Berl). 2014 Sep;231(17):3325-32. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3844 mL | 16.9222 mL | 33.8444 mL | 84.6110 mL |
| 5 mM | 0.6769 mL | 3.3844 mL | 6.7689 mL | 16.9222 mL | |
| 10 mM | 0.3384 mL | 1.6922 mL | 3.3844 mL | 8.4611 mL | |
| 15 mM | 0.2256 mL | 1.1281 mL | 2.2563 mL | 5.6407 mL | |
| 20 mM | 0.1692 mL | 0.8461 mL | 1.6922 mL | 4.2305 mL | |
| 25 mM | 0.1354 mL | 0.6769 mL | 1.3538 mL | 3.3844 mL | |
| 30 mM | 0.1128 mL | 0.5641 mL | 1.1281 mL | 2.8204 mL | |
| 40 mM | 0.0846 mL | 0.4231 mL | 0.8461 mL | 2.1153 mL | |
| 50 mM | 0.0677 mL | 0.3384 mL | 0.6769 mL | 1.6922 mL | |
| 60 mM | 0.0564 mL | 0.2820 mL | 0.5641 mL | 1.4102 mL | |
| 80 mM | 0.0423 mL | 0.2115 mL | 0.4231 mL | 1.0576 mL | |
| 100 mM | 0.0338 mL | 0.1692 mL | 0.3384 mL | 0.8461 mL |
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