Etiocholanolone-d₅

Name: Etiocholanolone-d 5
Brand: MedChemExpress
SKU: HY-113320S
Rating: 4.5 (1 reviews)

Cat. No.: HY-113320S Purity: 99.20%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Etiocholanolone-d₅ is the deuterium labeled Etiocholanolone. Etiocholanolone (5β-Androsterone) is the excreted metabolite of testosterone and has anticonvulsant activity[1]. Etiocholanolone is a less potent neurosteroid positive allosteric modulator (PAM) of the GABAA receptor than its enantiomer form[2].

For research use only. We do not sell to patients.

Etiocholanolone-d<sub>5</sub> Chemical Structure

Etiocholanolone-d₅ Chemical Structure

CAS No. : 1620102-33-1

Size	Price	Stock	Quantity
1 mg	USD 1100	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Etiocholanolone-d₅:

Etiocholanolone In-stock

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

295.47

Formula

C₁₉H₂₅D₅O₂

CAS No.

1620102-33-1

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@]3([H])[C@](CC[C@]1([H])C([2H])([2H])[C@](C([2H])([2H])C2)([2H])O)([H])[C@@]4([H])[C@](CC3)(C(CC4)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (169.22 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3844 mL	16.9222 mL	33.8444 mL
5 mM	0.6769 mL	3.3844 mL	6.7689 mL
10 mM	0.3384 mL	1.6922 mL	3.3844 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.20%

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Data Sheet (278 KB) SDS (0 KB)

COA (257 KB) HNMR (501 KB) LCMS (426 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Ping Li,et al. Natural and Enantiomeric Etiocholanolone Interact With Distinct Sites on the Rat alpha1beta2gamma2L GABAA Receptor. Mol Pharmacol. 2007 Jun;71(6):1582-90. [Content Brief]

[3]. Dorota Zolkowska, et al. Anticonvulsant Potencies of the Enantiomers of the Neurosteroids Androsterone and Etiocholanolone Exceed Those of the Natural Forms. Psychopharmacology (Berl). 2014 Sep;231(17):3325-32. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3844 mL	16.9222 mL	33.8444 mL	84.6110 mL
	5 mM	0.6769 mL	3.3844 mL	6.7689 mL	16.9222 mL
	10 mM	0.3384 mL	1.6922 mL	3.3844 mL	8.4611 mL
	15 mM	0.2256 mL	1.1281 mL	2.2563 mL	5.6407 mL
	20 mM	0.1692 mL	0.8461 mL	1.6922 mL	4.2305 mL
	25 mM	0.1354 mL	0.6769 mL	1.3538 mL	3.3844 mL
	30 mM	0.1128 mL	0.5641 mL	1.1281 mL	2.8204 mL
	40 mM	0.0846 mL	0.4231 mL	0.8461 mL	2.1153 mL
	50 mM	0.0677 mL	0.3384 mL	0.6769 mL	1.6922 mL
	60 mM	0.0564 mL	0.2820 mL	0.5641 mL	1.4102 mL
	80 mM	0.0423 mL	0.2115 mL	0.4231 mL	1.0576 mL
	100 mM	0.0338 mL	0.1692 mL	0.3384 mL	0.8461 mL