1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. Etiocholanolone

Etiocholanolone (Synonyms: 5β-Androsterone)

Cat. No.: HY-113320 Purity: ≥98.0%
Handling Instructions

Etiocholanolone (5β-Androsterone) is the excreted metabolite of testosterone and has anticonvulsant activity. Etiocholanolone is a less potent neurosteroid positive allosteric modulator (PAM) of the GABAA receptor than its enantiomer form.

For research use only. We do not sell to patients.

Etiocholanolone Chemical Structure

Etiocholanolone Chemical Structure

CAS No. : 53-42-9

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5 mg USD 70 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Etiocholanolone (5β-Androsterone) is the excreted metabolite of testosterone and has anticonvulsant activity[1]. Etiocholanolone is a less potent neurosteroid positive allosteric modulator (PAM) of the GABAA receptor than its enantiomer form[2].

In Vitro

Etiocholanolone (10 μM) coapplication with GABA leads to an increase in the relative frequency of long openings (fraction of OT3, site A2 effect), but it is ineffective at increasing the duration of long openings (site B effect) or at decreasing the relative frequency of the activation-related closed time component (site A1 effect)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Etiocholanolone (intraperitoneal injection; 0-109.1 mg/kg; single dose) exhibits ED50 values of 57.6 and 109.1 mg/kg in the 6-Hz and PTZ tests, respectively. Protective activity in the 6-Hz test of 5β,3α-A persists for 2 h and is shorter than ent-5β,3α-A treatment (3 hours) in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

290.44

Formula

C₁₉H₃₀O₂

CAS No.

53-42-9

SMILES
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Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (344.31 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4431 mL 17.2153 mL 34.4305 mL
5 mM 0.6886 mL 3.4431 mL 6.8861 mL
10 mM 0.3443 mL 1.7215 mL 3.4431 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.61 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.61 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.61 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Etiocholanolone5β-AndrosteroneGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptoranticonvulsantepilepsyantiepilepticInhibitorinhibitorinhibit

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Product Name:
Etiocholanolone
Cat. No.:
HY-113320
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