1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. Etiocholanolone

Etiocholanolone (Synonyms: 5β-Androsterone)

Cat. No.: HY-113320
Handling Instructions

Etiocholanolone (5β-Androsterone) is the excreted metabolite of testosterone and has anticonvulsant activity. Etiocholanolone is a less potent neurosteroid positive allosteric modulator (PAM) of the GABAA receptor than its enantiomer form.

For research use only. We do not sell to patients.

Etiocholanolone Chemical Structure

Etiocholanolone Chemical Structure

CAS No. : 53-42-9

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Description

Etiocholanolone (5β-Androsterone) is the excreted metabolite of testosterone and has anticonvulsant activity[1]. Etiocholanolone is a less potent neurosteroid positive allosteric modulator (PAM) of the GABAA receptor than its enantiomer form[2].

In Vitro

Etiocholanolone (10 μM) coapplication with GABA leads to an increase in the relative frequency of long openings (fraction of OT3, site A2 effect), but it is ineffective at increasing the duration of long openings (site B effect) or at decreasing the relative frequency of the activation-related closed time component (site A1 effect)[2].

In Vivo

Etiocholanolone (intraperitoneal injection; 0-109.1 mg/kg; single dose) exhibits ED50 values of 57.6 and 109.1 mg/kg in the 6-Hz and PTZ tests, respectively. Protective activity in the 6-Hz test of 5β,3α-A persists for 2 h and is shorter than ent-5β,3α-A treatment (3 hours) in mice[1].

Molecular Weight

290.44

Formula

C₁₉H₃₀O₂

CAS No.

53-42-9

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Etiocholanolone5β-AndrosteroneGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptoranticonvulsantepilepsyantiepilepticInhibitorinhibitorinhibit

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