Tetrahydrocortisol

Cat. No.: HY-129630 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Tetrahydrocortisol is cortisol metabolite. The urinary Tetrahydrocortisol/Tetrahydrocortisone ratio decreases with increasing 11β-hydroxysteroid dehydrogenase (11β-HSD) activity.

For research use only. We do not sell to patients.

Tetrahydrocortisol Chemical Structure

CAS No. : 53-02-1

Size	Price	Stock	Quantity
Solution
10 mM * 1 mL in DMSO	USD 282	In-stock	Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL ready for reconstitution	USD 282	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Description

Tetrahydrocortisol is cortisol metabolite. The urinary Tetrahydrocortisol/Tetrahydrocortisone ratio decreases with increasing 11β-hydroxysteroid dehydrogenase (11β-HSD) activity^[1]^[2].

IC₅₀ & Target

Human Endogenous Metabolite

Molecular Weight

366.49

Appearance

Solid

Formula

C₂₁H₃₄O₅

CAS No.

53-02-1

SMILES

C[[email protected]@]12[[email protected]](C(CO)=O)(O)CC[[email protected]@]1([H])[[email protected]]3([H])CC[[email protected]]4([H])C[[email protected]](O)CC[[email protected]]4(C)[[email protected]@]3([H])[[email protected]@H](O)C2

Structure Classification

Steroids

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (136.43 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7286 mL	13.6429 mL	27.2859 mL
5 mM	0.5457 mL	2.7286 mL	5.4572 mL
10 mM	0.2729 mL	1.3643 mL	2.7286 mL

*Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 1.25 mg/mL (3.41 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 1.25 mg/mL (3.41 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO 90% corn oil
Solubility: ≥ 1.25 mg/mL (3.41 mM); Clear solution

*All of the co-solvents are available by MCE.

Purity & Documentation

Purity: ≥98.0%

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Data Sheet (274 KB) SDS (251 KB)

COA (251 KB) HNMR (275 KB)

Handling Instructions (2659 KB)

References

[1]. Webster SP, et al. Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™). Br J Pharmacol. 2017 Mar;174(5):396-408. [Content Brief]

[2]. Turpeinen U, et al. Determination of free tetrahydrocortisol and tetrahydrocortisone ratio in urine by liquid chromatography-tandem mass spectrometry. Scand J Clin Lab Invest. 2006;66(2):147-59. [Content Brief]

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords:

Tetrahydrocortisol53-02-1Endogenous MetaboliteInhibitorinhibitorinhibit

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Tetrahydrocortisol

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•Related Screening Libraries:

Biological Activity

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Molarity Calculator

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The molarity calculator equation

The dilution calculator equation

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