β-Cyclodextrin
Based on 9 publication(s) in Google Scholar
β-Cyclodextrin is a cyclic polysaccharide composed of seven units of glucose (α-D-glucopyranose) linked by α-(1,4) type bonds. β-Cyclodextrin has often been used to enhance the solubility of agents. β-Cyclodextrin has anti-influenza virus H1N1 activities.
For research use only. We do not sell to patients.
- Purity: 99.95%
- CAS No.: 7585-39-9
- Formula: C42H70O35
- Molecular Weight:1134.98
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) β-Cyclodextrin
More- Immunity. 2021 May 11;54(5):962-975.e8. [Abstract]
- Cell Mol Immunol. 2024 Aug;21(8):826-841. [Abstract]
- Cell Death Differ. 2024 May 8. [Abstract]
- Mater Today Bio. 2025 Aug 11:34:102179. [Abstract]
- Cell Rep. 2024 Nov 9;43(11):114962. [Abstract]
- Int J Mol Med. 2025 May;55(5):78. [Abstract]
- Intensive Care Med Exp. 2024 Jul 8;12(1):64. [Abstract]
- JBMR Plus. 2026 Jan 14;10(3):ziag005. [Abstract]
- J Dig Dis. 2024 Jul;25(7):453-462. [Abstract]
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Biological Activity
β-Cyclodextrin (Beta-cyclodextrin; β-CD) is a cyclic polysaccharide composed of seven units of glucose (α-D-glucopyranose) linked by α-(1,4) type bonds, which presents a hydrophilic external surface and a hydrophobic internal cavity[1]. In the pharmaceutical industry, β-Cyclodextrin (β-CD) has often been used to enhance the solubility of drugs, such as indomethacin, naringin, celecoxib, and citric acid[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 7585-39-9
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Appearance Solid
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Molecular Weight 1134.98
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Formula C42H70O35
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Color White to off-white
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SMILES
OC[C@@H]1[C@]2([H])[C@@H]([C@@H](O)[C@](O[C@]3([H])[C@H](O[C@@](O[C@]4([H])[C@H](O[C@@](O[C@]5([H])[C@H](O[C@@](O[C@@]6([H])[C@H](O)[C@@H](O)[C@@](O[C@@H]6CO)([H])O[C@@]7([H])[C@H](O)[C@@H](O)[C@@](O[C@@H]7CO)([H])O[C@@]8([H])[C@H](O)[C@@H](O)[C@@](O[C@@H]8CO)([H])O2)([H])[C@H](O)[C@H]5O)CO)([H])[C@H](O)[C@H]4O)CO)([H])[C@H](O)[C@H]3O)CO)([H])O1)O
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Synonyms
Betadex
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Initial Source
Bacillus
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (9)
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Journal Impact Factor
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Most Recent
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Immunity
Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING. [Abstract]2021 May 11;54(5):962-975.e8. PMID: 33857420 -
Cell Mol Immunol
Depleting profibrotic macrophages using bioactivated in vivo assembly peptides ameliorates kidney fibrosis. [Abstract]2024 Aug;21(8):826-841. PMID: 38871810 -
Cell Death Differ
2024 May 8. PMID: 38719928 -
Mater Today Bio
Brinzolamide encapsulated β-cyclodextrin-chondroitin sulfate nanocomplexes anchored chitosan/polycaprolactone nanofibers as an ocular insert for glaucoma treatment. [Abstract]2025 Aug 11:34:102179. PMID: 40838214
β-Cyclodextrin purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Aug 11:34:102179. [Abstract]
β-Cyclodextrin (β-CD) (0-15 mM; 10 mL; 36 h; 37 ± 2 ℃) substantially enhanced the solubility of BRZ in PBS.
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Cell Rep
ZDHHC3-mediated SCAP S-acylation promotes cholesterol biosynthesis and tumor immune escape in hepatocellular carcinoma. [Abstract]2024 Nov 9;43(11):114962. PMID: 39522165
β-Cyclodextrin purchased from MedChemExpress. Usage Cited in: Cell Rep. 2024 Nov 9;43(11):114962. [Abstract]
β-Cyclodextrin (β-CD) (5 mM; 6 h) counteracted the promoted ratio of CD4+IFN-γ+ cells and CD4+GZMB+ cells induced by depletion of Zdhhc3 in Hep1-6 cells.
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Int J Mol Med
Platelet activation stimulates macrophages to enhance ulcerative colitis through PF4/CXCR3 signaling. [Abstract]2025 May;55(5):78. PMID: 40084691 -
Intensive Care Med Exp
Effects of sodium-glucose transporter-2 inhibition on systemic hemodynamics, renal function, and intra-renal oxygenation in sepsis-associated acute kidney injury. [Abstract]2024 Jul 8;12(1):64. PMID: 38977627 -
JBMR Plus
Inhibition of FGFR signaling with infigratinib improves linear bone growth in the female Aga2/+ mouse model of osteogenesis imperfecta. [Abstract]2026 Jan 14;10(3):ziag005. PMID: 41641077 -
J Dig Dis
Inhibition of FoxO1 ameliorates hepatic steatosis and hepatitis in nonalcoholic steatohepatitis mice through regulation of gut microbiota. [Abstract]2024 Jul;25(7):453-462. PMID: 39211938
Solvent & Solubility
H2O : 7 mg/mL (6.17 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (290 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
[1]. Campos EVR, et al. Chitosan nanoparticles functionalized with β-cyclodextrin: a promising carrier for botanicalpesticides. Sci Rep. 2018 Feb 1;8(1):2067. [Content Brief]
[2]. Cui L, et al. Effect of β-cyclodextrin complexation on solubility and enzymatic conversion of naringin. Int J Mol Sci. 2012 Nov 5;13(11):14251-61. [Content Brief]
[3]. Goncharova EP, et al. A Novel Sulfonated Derivative of β-Cyclodextrin Effectively Inhibits Influenza A Virus Infection in vitro and in vivo. Acta Naturae. 2019 Jul-Sep;11(3):20-30. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.8811 mL | 4.4054 mL | 8.8107 mL | 22.0268 mL |
| 5 mM | 0.1762 mL | 0.8811 mL | 1.7621 mL | 4.4054 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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