Monomethyl phthalate-d4
Monomethyl phthalate-d4 (2-(Methoxycarbonyl)benzoic acid-d4) is the deuterium labeled Monomethyl phthalate. Monomethyl phthalate is a phthalate metabolite. Monomethyl phthalate acts as a urinary biomarker of phthalates exposure and can be used as a standard for the determination of thyroid cancer and benign nodule.
For research use only. We do not sell to patients.
- CAS No.: 1276197-40-0
- Formula: C9H4D4O4
- Molecular Weight:184.18
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1276197-40-0
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Unlabeled Cas 4376-18-5
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Appearance Solid
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Molecular Weight 184.18
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Formula C9H4D4O4
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Color White to off-white
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SMILES
O=C(O)C1=C([2H])C([2H])=C([2H])C([2H])=C1C(OC)=O
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Synonyms
2-(Methoxycarbonyl)benzoic acid-d4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (542.95 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Chong Liu, et al. Urinary biomarkers of phthalates exposure and risks of thyroid cancer and benign nodule. J Hazard Mater. 2020 Feb 5;383:121189. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 5.4295 mL | 27.1474 mL | 54.2947 mL | 135.7368 mL |
| 5 mM | 1.0859 mL | 5.4295 mL | 10.8589 mL | 27.1474 mL | |
| 10 mM | 0.5429 mL | 2.7147 mL | 5.4295 mL | 13.5737 mL | |
| 15 mM | 0.3620 mL | 1.8098 mL | 3.6196 mL | 9.0491 mL | |
| 20 mM | 0.2715 mL | 1.3574 mL | 2.7147 mL | 6.7868 mL | |
| 25 mM | 0.2172 mL | 1.0859 mL | 2.1718 mL | 5.4295 mL | |
| 30 mM | 0.1810 mL | 0.9049 mL | 1.8098 mL | 4.5246 mL | |
| 40 mM | 0.1357 mL | 0.6787 mL | 1.3574 mL | 3.3934 mL | |
| 50 mM | 0.1086 mL | 0.5429 mL | 1.0859 mL | 2.7147 mL | |
| 60 mM | 0.0905 mL | 0.4525 mL | 0.9049 mL | 2.2623 mL | |
| 80 mM | 0.0679 mL | 0.3393 mL | 0.6787 mL | 1.6967 mL | |
| 100 mM | 0.0543 mL | 0.2715 mL | 0.5429 mL | 1.3574 mL |
Monomethyl phthalate-d4 Related Classifications
HY-Y1097S Related Classifications
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