1. Immunology/Inflammation
    Metabolic Enzyme/Protease
  2. NOD-like Receptor (NLR)
    Endogenous Metabolite
  3. N4-Acetylcytidine triphosphate

N4-Acetylcytidine triphosphate (Synonyms: ac4CTP)

Cat. No.: HY-111815
Handling Instructions

N4-Acetylcytidine triphosphate is a endogenous nucleoside metabolite from the degradation of tRNA, primes and activates NLRP3 inflammation by inducing HMGB1 expression.

For research use only. We do not sell to patients.

N4-Acetylcytidine triphosphate Chemical Structure

N4-Acetylcytidine triphosphate Chemical Structure

CAS No. : 1428903-57-4

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Description

N4-Acetylcytidine triphosphate is a endogenous nucleoside metabolite from the degradation of tRNA, primes and activates NLRP3 inflammation by inducing HMGB1 expression[1].

IC50 & Target

NLRP3[1]

In Vitro

N4-Acetylcytidine (0.3  mM or 1.0  mM) upregulates NF-κB and NLRP3 expression BV2 microglia, and this calls for HMGB1 expression and release[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

525.19

Formula

C₁₁H₁₈N₃O₁₅P₃

CAS No.

1428903-57-4

SMILES

O[[email protected]@H]([[email protected]]([[email protected]](N1C(N=C(C=C1)NC(C)=O)=O)O2)O)[[email protected]]2COP(O)(OP(OP(O)(O)=O)(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
N4-Acetylcytidine triphosphate
Cat. No.:
HY-111815
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N4-Acetylcytidine triphosphate

Cat. No.: HY-111815