N4-Acetylcytidine triphosphate
Based on 1 publication(s) in Google Scholar
N4-Acetylcytidine triphosphate is efficiently used as a substrate in T7 Polymerase-catalyzed in vitro transcription and can be incorporated into multiple templates.
For research use only. We do not sell to patients.
- CAS No.: 1428903-57-4
- Formula: C11H18N3O15P3
- Molecular Weight:525.19
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) N4-Acetylcytidine triphosphate
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
N4-Acetylcytidine triphosphate (0.1-2 mM; 24-48 h) inhibits BV2 microglia cell grwoth[1]. N4-Acetylcytidine triphosphate (0.3-1 mM; 3-6 h) activates NFκB signaling and upregulates NLRP3 expression[1]. N4-Acetylcytidine triphosphate (0.3-1 mM; 3 h) increases the expression level of HMGB1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BV2 microglia
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Concentration:0.1-2 mM
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Incubation Time:24-48 hours
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Result:Significantly inhibited BV2 microglia cell growth util cultured for 48 hours with a concentration of 0.3 mM.
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Cell Line:BV2 microglia
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Concentration:0.3 and 1 mM
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Incubation Time:3 and 6 hours
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Result:Increased NLRP3 and NFκB expression at both mRNA and protein levels, activated the NFκB signaling.
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Cell Line:BV2 microglia
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Concentration:0.3 and 1 mM
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Incubation Time:3 hours
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Result:Induced HMGB1 expression and it is necessary for NFkB signaling, NLRP3 expression and persistent HMGB1 expression.
Chemical Information
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CAS No. 1428903-57-4
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Molecular Weight 525.19
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Formula C11H18N3O15P3
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SMILES
O[C@@H]([C@H]([C@H](N1C(N=C(C=C1)NC(C)=O)=O)O2)O)[C@H]2COP(O)(OP(OP(O)(O)=O)(O)=O)=O
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Synonyms
ac4CTP
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Nucleic Acids Res
2022 Sep 9;50(16):9339-9354. PMID: 35971620
Solvent & Solubility
H2O : ≥ 250 mg/mL (476.02 mM)
* "≥" means soluble, but saturation unknown.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.9041 mL | 9.5204 mL | 19.0407 mL | 47.6018 mL |
| 5 mM | 0.3808 mL | 1.9041 mL | 3.8081 mL | 9.5204 mL | |
| 10 mM | 0.1904 mL | 0.9520 mL | 1.9041 mL | 4.7602 mL | |
| 15 mM | 0.1269 mL | 0.6347 mL | 1.2694 mL | 3.1735 mL | |
| 20 mM | 0.0952 mL | 0.4760 mL | 0.9520 mL | 2.3801 mL | |
| 25 mM | 0.0762 mL | 0.3808 mL | 0.7616 mL | 1.9041 mL | |
| 30 mM | 0.0635 mL | 0.3173 mL | 0.6347 mL | 1.5867 mL | |
| 40 mM | 0.0476 mL | 0.2380 mL | 0.4760 mL | 1.1900 mL | |
| 50 mM | 0.0381 mL | 0.1904 mL | 0.3808 mL | 0.9520 mL | |
| 60 mM | 0.0317 mL | 0.1587 mL | 0.3173 mL | 0.7934 mL | |
| 80 mM | 0.0238 mL | 0.1190 mL | 0.2380 mL | 0.5950 mL | |
| 100 mM | 0.0190 mL | 0.0952 mL | 0.1904 mL | 0.4760 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
N4-Acetylcytidine triphosphate Related Classifications
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