N4-Acetylcytidine triphosphate sodium
Based on 1 publication(s) in Google Scholar
N4-Acetylcytidine triphosphate sodium is efficiently used as a substrate in T7 Polymerase-catalyzed in vitro transcription and it can be incorporated into multiple templates.
For research use only. We do not sell to patients.
- CAS No.: 2803886-33-9
- Formula: C11H14N3Na4O15P3
- Molecular Weight:613.12
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Storage:
-80°C, protect from light, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) N4-Acetylcytidine triphosphate sodium
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
N4-Acetylcytidine triphosphate sodium (0.1-2 mM; 24-48 h) inhibits BV2 microglia cell grwoth[1]. N4-Acetylcytidine triphosphate sodium (0.3-1 mM; 3-6 h) activates NFκB signaling and upregulates NLRP3 expression[1]. N4-Acetylcytidine triphosphate sodium (0.3-1 mM; 3 h) increases the expression level of HMGB1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BV2 microglia
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Concentration:0.1-2 mM
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Incubation Time:24-48 hours
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Result:Significantly inhibited BV2 microglia cell growth util cultured for 48 hours with a concentration of 0.3 mM.
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Cell Line:BV2 microglia
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Concentration:0.3 and 1 mM
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Incubation Time:3 and 6 hours
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Result:Increased NLRP3 and NFκB expression at both mRNA and protein levels, activated the NFκB signaling.
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Cell Line:BV2 microglia
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Concentration:0.3 and 1 mM
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Incubation Time:3 hours
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Result:Induced HMGB1 expression and it is necessary for NFkB signaling, NLRP3 expression and persistent HMGB1 expression.
Chemical Information
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CAS No. 2803886-33-9
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Appearance Solid
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Molecular Weight 613.12
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Formula C11H14N3Na4O15P3
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Color White to yellow
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SMILES
O[C@@H]([C@H]([C@H](N1C(N=C(C=C1)NC(C)=O)=O)O2)O)[C@H]2COP(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O
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Synonyms
ac4CTP sodium
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Shipping
Shipping with dry ice.
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Storage
-80°C, protect from light, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
Publications (1)
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Journal Impact Factor
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Most Recent
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Nucleic Acids Res
2022 Sep 9;50(16):9339-9354. PMID: 35971620
Solvent & Solubility
H2O : 100 mg/mL (163.10 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 25 mg/mL (40.78 mM); Clear solution; Need ultrasonic and warming
Purity & Documentation
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Data Sheet (284 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.6310 mL | 8.1550 mL | 16.3100 mL | 40.7751 mL |
| 5 mM | 0.3262 mL | 1.6310 mL | 3.2620 mL | 8.1550 mL | |
| 10 mM | 0.1631 mL | 0.8155 mL | 1.6310 mL | 4.0775 mL | |
| 15 mM | 0.1087 mL | 0.5437 mL | 1.0873 mL | 2.7183 mL | |
| 20 mM | 0.0816 mL | 0.4078 mL | 0.8155 mL | 2.0388 mL | |
| 25 mM | 0.0652 mL | 0.3262 mL | 0.6524 mL | 1.6310 mL | |
| 30 mM | 0.0544 mL | 0.2718 mL | 0.5437 mL | 1.3592 mL | |
| 40 mM | 0.0408 mL | 0.2039 mL | 0.4078 mL | 1.0194 mL | |
| 50 mM | 0.0326 mL | 0.1631 mL | 0.3262 mL | 0.8155 mL | |
| 60 mM | 0.0272 mL | 0.1359 mL | 0.2718 mL | 0.6796 mL | |
| 80 mM | 0.0204 mL | 0.1019 mL | 0.2039 mL | 0.5097 mL | |
| 100 mM | 0.0163 mL | 0.0816 mL | 0.1631 mL | 0.4078 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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